Next Article in Journal
Evaluation of MCT1, MCT4 and CD147 Genes in Peripheral Blood Cells of Breast Cancer Patients and Their Potential Use as Diagnostic and Prognostic Markers
Previous Article in Journal
Anti-Obesity Effect of Bombus ignitus Queen Glycosaminoglycans in Rats on a High-Fat Diet
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(3), 682; doi:10.3390/ijms18030682

A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging

1
Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Korea
2
Research Institute of Biotechnology and Medical Converged Science, Dongguk University (Seoul),Goyang 10326, Korea
3
The Food and Culture Institute, Pulmuone Co., Ltd., Seoul 03722, Korea
4
Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
5
School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea
*
Authors to whom correspondence should be addressed.
Received: 24 January 2017 / Revised: 28 February 2017 / Accepted: 13 March 2017 / Published: 22 March 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [2778 KB, uploaded 23 March 2017]   |  

Abstract

Soybean-derived isoflavones have been investigated for their preventative effects against UV-induced symptoms of skin damage including wrinkle formation and inflammation. Haematococcus pluvialis is a freshwater species of Chlorophyta that contains high concentrations of the natural carotenoid pigment astaxanthin. Astaxanthin is known to be involved in retinoic acid receptor (RAR) signaling and previously been associated with the inhibition of activator protein (AP)-1 dependent transcription. Based on previous studies, we hypothesized that a combination of soy extract (SE) and Haematococcus extract (HE) may prevent UVB-induced photoaging through specific signaling pathways, as measured by UVB-induced wrinkling on hairless mice skin and expression changes in human dermal fibroblasts (HDFs). The 1:2 ratio of SE and HE mixture (SHM) showed the optimal benefit in vivo. SHM was found to inhibit wrinkle formation via the downregulation of matrix metalloproteinase (MMP)-1 mRNA and protein expression. SHM also inhibited mitogen-activated protein kinase (MAPK) phosphorylation and the transactivation of AP-1 which plays an important role in regulating MMP expression. These results highlight the potential for SHM to be developed as a therapeutic agent to prevent UVB-induced skin wrinkling. View Full-Text
Keywords: soybean; Haematococcus; ultraviolet B; photoaging soybean; Haematococcus; ultraviolet B; photoaging
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shin, J.; Kim, J.-E.; Pak, K.-J.; Kang, J.I.; Kim, T.-S.; Lee, S.-Y.; Yeo, I.-H.; Park, J.H.Y.; Kim, J.H.; Kang, N.J.; Lee, K.W. A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging. Int. J. Mol. Sci. 2017, 18, 682.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top