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Int. J. Mol. Sci. 2017, 18(3), 601; doi:10.3390/ijms18030601

Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis

1
Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea
2
Department of Bio-Informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida 203201, India
3
Department of Emergency Medicine, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Ali Mobasheri and Charles J. Malemud
Received: 30 November 2016 / Revised: 26 February 2017 / Accepted: 6 March 2017 / Published: 12 March 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
View Full-Text   |   Download PDF [942 KB, uploaded 12 March 2017]   |  

Abstract

Osteoarthritis (OA) is a degenerative disease of the joints and is one of the leading causes of disability in adults. However, there are no key therapeutics for OA and medical treatment is based on managing the symptoms and slowing down progression of the disease. Diagnostics based on clinical examination and radiography have provided little information about metabolic changes in joint tissues, disease onset and progression. Due to lack of effective methods for early detection and evaluation of treatment outcome, the measurement of biochemical markers (biomarkers) shows promise as a prospective method aiding in disease monitoring. OA biomarkers that are present in biological fluids such as blood, urine and synovial fluid, sources that are easily isolated from body, are of particular interest. Moreover, there are increasingly more studies identifying and developing new biomarkers for OA. In this review, efforts have been made to summarize the biomarkers that have been reported in recent studies on patients. We also tried to classify biomarkers according to tissue metabolism (bone, cartilage and synovial metabolism markers), pathological pathways (inflammatory and genetic markers) and biological function (chemokines, growth factors, acute phase proteins, etc.). View Full-Text
Keywords: osteoarthritis (OA); biomarker; marker of joint metabolism; inflammatory marker; genetic marker osteoarthritis (OA); biomarker; marker of joint metabolism; inflammatory marker; genetic marker
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MDPI and ACS Style

Nguyen, L.T.; Sharma, A.R.; Chakraborty, C.; Saibaba, B.; Ahn, M.-E.; Lee, S.-S. Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis. Int. J. Mol. Sci. 2017, 18, 601.

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