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Int. J. Mol. Sci. 2017, 18(3), 577; doi:10.3390/ijms18030577

Trauma and Stem Cells: Biology and Potential Therapeutic Implications

1
School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia
2
Department of Traumatology, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Cory J. Xian
Received: 17 January 2017 / Revised: 1 March 2017 / Accepted: 2 March 2017 / Published: 7 March 2017
(This article belongs to the Special Issue Advances in Bone and Cartilage Research)
View Full-Text   |   Download PDF [1751 KB, uploaded 7 March 2017]   |  

Abstract

Trauma may cause irreversible tissue damage and loss of function despite current best practice. Healing is dependent both on the nature of the injury and the intrinsic biological capacity of those tissues for healing. Preclinical research has highlighted stem cell therapy as a potential avenue for improving outcomes for injuries with poor healing capacity. Additionally, trauma activates the immune system and alters stem cell behaviour. This paper reviews the current literature on stem cells and its relevance to trauma care. Emphasis is placed on understanding how stem cells respond to trauma and pertinent mechanisms that can be utilised to promote tissue healing. Research involving notable difficulties in trauma care such as fracture non-union, cartilage damage and trauma induced inflammation is discussed further. View Full-Text
Keywords: trauma; stem cells; inflammation; DAMP; healing trauma; stem cells; inflammation; DAMP; healing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Thurairajah, K.; Broadhead, M.L.; Balogh, Z.J. Trauma and Stem Cells: Biology and Potential Therapeutic Implications. Int. J. Mol. Sci. 2017, 18, 577.

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