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Int. J. Mol. Sci. 2017, 18(3), 575; doi:10.3390/ijms18030575

Serum-Infliximab Trough Levels in 45 Children with Inflammatory Bowel Disease on  Maintenance Treatment

1
Department of Gastroenterology, Sachs’ Children and Youth Hospital, SE-11883 Stockholm, Sweden
2
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institute, SE-11883 Stockholm, Sweden
3
Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, SE-17776 Stockholm, Sweden
4
Department of Medicine Solna, Karolinska Institute, SE-17776 Stockholm, Sweden
5
Department of Women’s and Children’s Health, Karolinska Institute, SE-11776 Stockholm, Sweden
6
Center for Clinical Research and Department of Pediatrics, Västmanland Hospital Vasteras, SE-72189 Västerås, Sweden
7
Department of Gastroenterology, Danderyds Hospital, SE-18288 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Academic Editors: Laurent Peyrin-Biroulet and Silvio Danese
Received: 27 October 2016 / Revised: 22 February 2017 / Accepted: 27 February 2017 / Published: 7 March 2017
View Full-Text   |   Download PDF [1079 KB, uploaded 7 March 2017]   |  

Abstract

The role of trough serum infliximab (s-IFX) and antibodies toward IFX (ATI) during maintenance treatment remains unclear in children. The aim of the present study was to investigate trough s-IFX and ATI to identify any correlation with inflammatory activity and clinical response in a pediatric inflammatory bowel disease (IBD) cohort. We investigated the s-IFX trough levels in pediatric IBD patients (n = 45) on maintenance IFX treatment. Ninety-three blood samples were collected and demographics, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and albumin were recorded. The mean s-IFX trough level was 5.2 µg/mL. The mean trough s-IFX level was significantly higher in the samples taken during remission (7.2 µg/mL) compared to active disease (4.5 µg/mL, p < 0.05). The trough s-IFX levels correlated with ESR, CRP, and albumin. S-IFX was undetectable in eight of the patients, all with positive ATI and active disease. Surprisingly, clinical and biochemical remission was observed at only 26 of the 93 visits. The correlation between dose variations and changes in trough s-IFX was not evident. In line with studies in adults, the s-IFX trough levels correlated with response to infliximab. View Full-Text
Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; trough levels; antibodies toward infliximab inflammatory bowel disease; Crohn’s disease; ulcerative colitis; trough levels; antibodies toward infliximab
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MDPI and ACS Style

Rolandsdotter, H.; Marits, P.; Sundin, U.; Wikström, A.-C.; Fagerberg, U.L.; Finkel, Y.; Eberhardson, M. Serum-Infliximab Trough Levels in 45 Children with Inflammatory Bowel Disease on  Maintenance Treatment. Int. J. Mol. Sci. 2017, 18, 575.

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