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Int. J. Mol. Sci. 2017, 18(3), 530; doi:10.3390/ijms18030530

The Role of the Melatoninergic System in Light-Entrained Behavior of Mice

1
Dr. Senckenbergische Anatomie II, Fachbereich Medizin, Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
2
Dr. Senckenbergisches Chronomedizinisches Institut, Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Russel J. Reiter
Received: 20 January 2017 / Revised: 16 February 2017 / Accepted: 26 February 2017 / Published: 1 March 2017
(This article belongs to the Special Issue Melatonin and Its Analogues: Experimental and Clinical Aspects)
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Abstract

The role of endogenous melatonin for the control of the circadian system under entrained conditions and for the determination of the chronotype is still poorly understood. Mice with deletions in the melatoninergic system (melatonin deficiency or the lack of melatonin receptors, respectively) do not display any obvious defects in either their spontaneous (circadian) or entrained (diurnal) rhythmic behavior. However, there are effects that can be detected by analyzing the periodicity of the locomotor behaviors in some detail. We found that melatonin-deficient mice (C57Bl), as well as melatonin-proficient C3H mice that lack the melatonin receptors (MT) 1 and 2 (C3H MT1,2 KO), reproduce their diurnal locomotor rhythms with significantly less accuracy than mice with an intact melatoninergic system. However, their respective chronotypes remained unaltered. These results show that one function of the endogenous melatoninergic system might be to stabilize internal rhythms under conditions of a steady entrainment, while it has no effects on the chronotype. View Full-Text
Keywords: circadian; stability; chronotype; melatonin; locomotor rhythm; diurnal circadian; stability; chronotype; melatonin; locomotor rhythm; diurnal
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Pfeffer, M.; Korf, H.-W.; Wicht, H. The Role of the Melatoninergic System in Light-Entrained Behavior of Mice. Int. J. Mol. Sci. 2017, 18, 530.

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