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Int. J. Mol. Sci. 2017, 18(3), 487; doi:10.3390/ijms18030487

Pancreatic Cancer-Induced Neutrophil Extracellular Traps: A Potential Contributor to Cancer-Associated Thrombosis

1
School of Biomedical Sciences, Curtin University, 6102 Perth, Australia
2
Curtin Health and Innovation Research Institute, Faculty of Health Sciences, Curtin University, 6102 Perth, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Denise Jackson
Received: 24 November 2016 / Revised: 30 January 2017 / Accepted: 13 February 2017 / Published: 24 February 2017
(This article belongs to the Special Issue Mechanisms of Platelet Thrombus Formation)
View Full-Text   |   Download PDF [3825 KB, uploaded 24 February 2017]   |  

Abstract

Pancreatic cancer (PaCa) is a highly metastatic cancer, and patients are at high risk of developing venous thromboembolism (VTE). Neutrophil extracellular traps (NETs) have been associated with cancer metastasis and cancer-associated thrombosis, but the ability of cancer to stimulate NET release is not known. The release of NETs has been shown to be a slow process and requires reactive oxygen species (ROS) production. Studies suggest that activated platelets are important mediators in the release. Here, we show that PaCa cells can stimulate the rapid release of NETs, independently of ROS production. We further assessed the role of platelets in PaCa-induced NETs and observed a trend of increased the NET release by PaCa-primed platelets. Additionally, NETs promoted thrombus formation under venous shear stress ex vivo. Taken together, our results suggest that PaCa-induced NETs can contribute to the high risk of venous thromboembolism development in PaCa patients, and reveal NETs as a potential therapeutic target. View Full-Text
Keywords: neutrophil extracellular traps; pancreatic cancer; platelets; venous thromboembolism neutrophil extracellular traps; pancreatic cancer; platelets; venous thromboembolism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Abdol Razak, N.; Elaskalani, O.; Metharom, P. Pancreatic Cancer-Induced Neutrophil Extracellular Traps: A Potential Contributor to Cancer-Associated Thrombosis. Int. J. Mol. Sci. 2017, 18, 487.

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