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Int. J. Mol. Sci. 2017, 18(2), 444; doi:10.3390/ijms18020444

Vegfa Impacts Early Myocardium Development in Zebrafish

1
Department of Pediatric Cardiology, Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
2
State Key Laboratory of Genetic Engineering, Zhongshan Hospital, School of Life Sciences, Fudan University, Shanghai 200438, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Michael Henein
Received: 14 January 2017 / Revised: 30 January 2017 / Accepted: 8 February 2017 / Published: 21 February 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Vascular endothelial growth factor A (Vegfa) signaling regulates cardiovascular development. However, the cellular mechanisms of Vegfa signaling in early cardiogenesis remain poorly understood. The present study aimed to understand the differential functions and mechanisms of Vegfa signaling in cardiac development. A loss-of-function approach was utilized to study the effect of Vegfa signaling in cardiogenesis. Both morphants and mutants for vegfaa display defects in cardiac looping and chamber formation, especially the ventricle. Vegfa regulates the heart morphogenesis in a dose-dependent manner. Furthermore, the initial fusion of the bilateral myocardium population is delayed rather than endocardium. The results demonstrate that Vegfa signaling plays a direct impact on myocardium fusion, indicating that it is the initial cause of the heart defects. The heart morphogenesis is regulated by Vegfa in a dose-dependent manner, and later endocardium defects may be secondary to impaired myocardium–endocardium crosstalk. View Full-Text
Keywords: Vegfa; cardiac fusion; zebrafish Vegfa; cardiac fusion; zebrafish
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Zhu, D.; Fang, Y.; Gao, K.; Shen, J.; Zhong, T.P.; Li, F. Vegfa Impacts Early Myocardium Development in Zebrafish. Int. J. Mol. Sci. 2017, 18, 444.

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