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Int. J. Mol. Sci. 2017, 18(2), 390; doi:10.3390/ijms18020390

Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-β1/Smads Signal Transduction Pathway in IgA Nephropathy

1
Department of Pathology, Harbin Medical University, Harbin 150081, China
2
Department of Microbiology, Harbin Medical University, Harbin 150081, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Gehua Zhen
Received: 6 January 2017 / Revised: 29 January 2017 / Accepted: 8 February 2017 / Published: 12 February 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Glomerular fibrosis has been shown to be closely related to the progression and prognosis of IgA nephropathy (IgAN). However, mechanism underlying IgAN glomerular fibrosis remains unclear. Recently, our study showed that plasma gelsolin (pGSN) was decreased in the serum of an IgAN mouse model and that pGSN deposition was found in the glomeruli. Another cytokine, TGF-β1, which is closely related to glomerular fibrosis, was also found to be highly expressed in the glomeruli. In the present study, we report that pGSN induces glomerular fibrosis through the TGF-β1/Smads signal transduction pathway. This is supported by the following findings: human mesangial cells (HMCs) show remarkable morphological changes and proliferation in response to co-stimulation with pGSN and polymeric IgA1 (pIgA1) from IgAN patients compared to other controls. Moreover, ELISA assays showed that more TGF-β1 secretion was found in HMCs supernatants in the co-stimulation group. Further experiments showed increased TGF-β1, Smad3, p-Smad2/3, Smad4, and collagen 1 and decreased Smad7 expression in the co-stimulation group. Our present study implied that the synergistic effect of pGSN and pIgA induced glomerular fibrosis via the TGF-β1/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients. View Full-Text
Keywords: IgA nephropathy; plasma gelsolin; glomerular fibrosis; TGF-β1/Smadssignal transduction pathway IgA nephropathy; plasma gelsolin; glomerular fibrosis; TGF-β1/Smadssignal transduction pathway
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MDPI and ACS Style

Zhang, L.; Han, C.; Ye, F.; He, Y.; Jin, Y.; Wang, T.; Wu, Y.; Jiang, Y.; Zhang, F.; Jin, X. Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-β1/Smads Signal Transduction Pathway in IgA Nephropathy. Int. J. Mol. Sci. 2017, 18, 390.

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