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Int. J. Mol. Sci. 2017, 18(2), 373; doi:10.3390/ijms18020373

Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Krüppel-Like Factor 2 and Adhesion Molecules

1
Division of Life Science, Daejeon University, Daejeon 300-716, Korea
2
Industrial Bio-materials Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea
3
Laboratory Animal Resource Center, KRIBB, Daejeon 305-806, Korea
4
Department of Biomolecular Science, Korea University of Science and Technology, KRIBB, Daejeon 305-806, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Battino and Leticia M. Estevinho
Received: 22 November 2016 / Revised: 23 January 2017 / Accepted: 6 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Nutraceuticals in Human Health and Disease)
View Full-Text   |   Download PDF [3966 KB, uploaded 19 February 2017]   |  

Abstract

Soy-leaf extracts exert their cardioprotective effects by inducing endothelium-dependent vasodilation in the arteries, and they favorably modulate the serum lipid profile. In this study, we investigated the atheroprotective effects of an ethanol extract of soy leaf (ESL) in human umbilical vein endothelial cells (HUVECs) and high-cholesterol diet (HCD)-fed low-density lipoprotein receptor deficient (LDLR−/−) mice. ESL induced the expression of Krüppel-like factor 2 (KLF2), an endothelial transcription factor, and endothelial nitric oxide synthase (eNOS), and suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) through moderate inflammatory signal activation, not only in tumor necrosis factor-α (TNF-α)-stimulated HUVECs but also in 7-ketocholesterol (7-KC)-stimulated HUVECs. ESL supplementation reduced aortic lesion formation in Western diet-fed LDLR−/− mice by 46% (p < 0.01) compared to the HCD group. ESL also markedly decreased the aortic expression levels of VCAM-1, ICAM-1, monocyte chemotactic protein-1 (MCP-1), TNF-α, IL-6, IL-1β, matrix metallopeptidase 9 (MMP-9), and fractalkine, while the expression of KLF2 was significantly increased. These results suggest that ESL supplementation has potential for preventing HCD-induced atherosclerosis effectively. View Full-Text
Keywords: adhesion molecule; atherosclerosis; inflammation; KLF2; soy leaf adhesion molecule; atherosclerosis; inflammation; KLF2; soy leaf
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MDPI and ACS Style

Han, J.-M.; Li, H.; Cho, M.-H.; Baek, S.-H.; Lee, C.-H.; Park, H.-Y.; Jeong, T.-S. Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Krüppel-Like Factor 2 and Adhesion Molecules. Int. J. Mol. Sci. 2017, 18, 373.

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