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Int. J. Mol. Sci. 2017, 18(2), 369; doi:10.3390/ijms18020369

Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants

1
Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN 55108, USA
2
Department of Restorative Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
3
BIOFORGE Group, University of Valladolid, Valladolid 4701, Spain
*
Authors to whom correspondence should be addressed.
Received: 29 December 2016 / Accepted: 3 February 2017 / Published: 9 February 2017
(This article belongs to the Special Issue Antimicrobial Polymers 2016)
View Full-Text   |   Download PDF [4764 KB, uploaded 13 February 2017]   |  

Abstract

The main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of osseointegration. Therefore, developing an implant to overcome these problems is of significant interest to the dental community. Chitosan has been reported to have good biocompatibility and anti-bacterial activity. An osseo-inductive recombinant elastin-like biopolymer (P-HAP), that contains a peptide derived from the protein statherin, has been reported to induce biomineralization and osteoblast differentiation. In this study, chitosan/P-HAP bi-layers were built on a titanium surface using a layer-by-layer (LbL) assembly technique. The difference in the water contact angle between consecutive layers, the representative peaks in diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and the changes in the topography between surfaces with a different number of bi-layers observed using atomic force microscopy (AFM), all indicated the successful establishment of chitosan/P-HAP LbL assembly on the titanium surface. The LbL-modified surfaces showed increased biomineralization, an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity against Streptococcus gordonii, a primary colonizer of tissues in the oral environment View Full-Text
Keywords: chitosan; elastin-like recombinamers; layer-by-layer; titanium; implant chitosan; elastin-like recombinamers; layer-by-layer; titanium; implant
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Govindharajulu, J.P.; Chen, X.; Li, Y.; Rodriguez-Cabello, J.C.; Battacharya, M.; Aparicio, C. Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants. Int. J. Mol. Sci. 2017, 18, 369.

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