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Open AccessCommunication
Int. J. Mol. Sci. 2017, 18(2), 316; doi:10.3390/ijms18020316

Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders

1
Department of Dermatology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea
2
Institute of Clinical Medical Research, Yeouido St. Mary’s Hostpital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea
3
Department of Life Science, Sookmyung Women’s University, Seoul 04310, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 31 October 2016 / Revised: 24 January 2017 / Accepted: 27 January 2017 / Published: 3 February 2017
(This article belongs to the Special Issue Inflammatory Skin Conditions)
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Abstract

Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group. In particular, the expression of Erdr1 was significantly decreased in patients with alopecia areata. We propose that Erdr1 downregulation might be involved in the pathogenesis of hair loss, and could be considered as a novel biomarker for hair loss disorders. View Full-Text
Keywords: hair loss; alopecia; erythroid differentiation regulator 1; inflammation hair loss; alopecia; erythroid differentiation regulator 1; inflammation
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Woo, Y.R.; Hwang, S.; Jeong, S.W.; Cho, D.H.; Park, H.J. Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders. Int. J. Mol. Sci. 2017, 18, 316.

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