Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders
AbstractErythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group. In particular, the expression of Erdr1 was significantly decreased in patients with alopecia areata. We propose that Erdr1 downregulation might be involved in the pathogenesis of hair loss, and could be considered as a novel biomarker for hair loss disorders. View Full-Text
Share & Cite This Article
Woo, Y.R.; Hwang, S.; Jeong, S.W.; Cho, D.H.; Park, H.J. Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders. Int. J. Mol. Sci. 2017, 18, 316.
Woo YR, Hwang S, Jeong SW, Cho DH, Park HJ. Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders. International Journal of Molecular Sciences. 2017; 18(2):316.Chicago/Turabian Style
Woo, Yu R.; Hwang, Sewon; Jeong, Seo W.; Cho, Dae H.; Park, Hyun J. 2017. "Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders." Int. J. Mol. Sci. 18, no. 2: 316.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.