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Int. J. Mol. Sci. 2017, 18(2), 302; doi:10.3390/ijms18020302

Gene–Environment Interactions in Preventive Medicine: Current Status and Expectations for the Future

Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama 241-8515, Japan
Received: 12 January 2017 / Accepted: 26 January 2017 / Published: 30 January 2017
(This article belongs to the Special Issue Gene–Environment Interactions)
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Abstract

The progression of many common disorders involves a complex interplay of multiple factors, including numerous different genes and environmental factors. Gene–environmental cohort studies focus on the identification of risk factors that cannot be discovered by conventional epidemiological methodologies. Such epidemiological methodologies preclude precise predictions, because the exact risk factors can be revealed only after detailed analyses of the interactions among multiple factors, that is, between genes and environmental factors. To date, these cohort studies have reported some promising results. However, the findings do not yet have sufficient clinical significance for the development of precise, personalized preventive medicine. Especially, some promising preliminary studies have been conducted in terms of the prevention of obesity. Large-scale validation studies of those preliminary studies, using a prospective cohort design and long follow-ups, will produce useful and practical evidence for the development of preventive medicine in the future. View Full-Text
Keywords: personalized medicine; genome; prospective cohort study; precision medicine personalized medicine; genome; prospective cohort study; precision medicine
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Narimatsu, H. Gene–Environment Interactions in Preventive Medicine: Current Status and Expectations for the Future. Int. J. Mol. Sci. 2017, 18, 302.

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