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Int. J. Mol. Sci. 2017, 18(2), 299; doi:10.3390/ijms18020299

Role of Aquaporin 1 Signalling in Cancer Development and Progression

1
Molecular Oncology, Basil Hetzel Institute, The Queen Elizabeth Hospital & Discipline of Physiology, School of Medicine, University of Adelaide, Adelaide, SA 5000, Australia
2
Molecular Oncology, Basil Hetzel Institute, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia
3
Discipline of Physiology, School of Medicine, University of Adelaide, Adelaide, SA 5000, Australia
4
Medical Oncology, The Queen Elizabeth Hospital & School of Medicine, University of Adelaide, Adelaide, SA 5000, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 16 December 2016 / Revised: 19 January 2017 / Accepted: 23 January 2017 / Published: 29 January 2017
(This article belongs to the Special Issue Aquaporin)
View Full-Text   |   Download PDF [920 KB, uploaded 10 February 2017]   |  

Abstract

Cancer is a major health burden worldwide. Despite the advances in our understanding of its pathogenesis and continued improvement in cancer management and outcomes, there remains a strong clinical demand for more accurate and reliable biomarkers of metastatic progression and novel therapeutic targets to abrogate angiogenesis and tumour progression. Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport. Recently, over-expression of AQP1 has been associated with many types of cancer as a distinctive clinical prognostic factor. This has prompted researchers to evaluate the link between AQP1 and cancer biological functions. Available literature implicates the role of AQP1 in tumour cell migration, invasion and angiogenesis. This article reviews the current understanding of AQP1-facilitated tumour development and progression with a focus on regulatory mechanisms and downstream signalling pathways. View Full-Text
Keywords: aquaporin 1; carcinogenesis; tumour angiogenesis; tumour cell migration aquaporin 1; carcinogenesis; tumour angiogenesis; tumour cell migration
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Tomita, Y.; Dorward, H.; Yool, A.J.; Smith, E.; Townsend, A.R.; Price, T.J.; Hardingham, J.E. Role of Aquaporin 1 Signalling in Cancer Development and Progression. Int. J. Mol. Sci. 2017, 18, 299.

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