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Int. J. Mol. Sci. 2017, 18(2), 272; doi:10.3390/ijms18020272

Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease

1
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2
Mr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Received: 25 December 2016 / Revised: 18 January 2017 / Accepted: 24 January 2017 / Published: 28 January 2017
(This article belongs to the Special Issue Translational Molecular Medicine & Molecular Drug Discovery)
View Full-Text   |   Download PDF [2357 KB, uploaded 4 February 2017]   |  

Abstract

Hippocampal neurogenesis plays a critical role in the formation of new neurons during learning and memory development. Attenuation of neurogenesis in the brain is one of the primary causes of dementia in Alzheimer’s disease (AD), and, conversely, modulating the process of hippocampal neurogenesis benefit patients with AD. Traditional Chinese medicine (TCM), particularly herbal medicine, has been in use for thousands of years in Asia and many regions of the world for the treatment of cancer, cardiovascular diseases and neurodegenerative diseases. In this review, we summarize the role of neurotrophic factors, signal transducing factors, epigenetic modulators and neurotransmitters in neurogenesis, and we also discuss the functions of several Chinese herbs and their active molecules in activating multiple pathways involved in neurogenesis. TCM herbs target pathways such as Notch, Wnt, Sonic Hedgehog and receptor tyrosine kinase pathway, leading to activation of a signaling cascade that ultimately enhances the transcription of several important genes necessary for neurogenesis. Given these pathway activating effects, the use of TCM herbs could be an effective therapeutic strategy for the treatment of AD. View Full-Text
Keywords: Keywords: Alzheimer’s disease; neurogenesis; traditional Chinese medicine Keywords: Alzheimer’s disease; neurogenesis; traditional Chinese medicine
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Sreenivasmurthy, S.G.; Liu, J.-Y.; Song, J.-X.; Yang, C.-B.; Malampati, S.; Wang, Z.-Y.; Huang, Y.-Y.; Li, M. Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease. Int. J. Mol. Sci. 2017, 18, 272.

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