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Int. J. Mol. Sci. 2017, 18(2), 246; doi:10.3390/ijms18020246

Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals

1
Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
2
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113 0033, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Irmgard Tegeder
Received: 26 December 2016 / Revised: 15 January 2017 / Accepted: 20 January 2017 / Published: 25 January 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1392 KB, uploaded 25 January 2017]   |  

Abstract

Transcription factors play critical roles in regulation of neural development and functions. A transcription factor Mblk-1 was previously reported from a screen for factors possibly important for the higher brain functions of the honeybee. This review first summarizes how Mblk-1 was identified, and then provides an overview of the studies of Mblk-1 and their homologs. Mblk-1 family proteins are found broadly in animals and are shown to affect transcription activities. Studies have revealed that the mammalian homologs can interact with several cofactors and together regulate transcription. Interestingly, a recent study using the mouse homologs, Mlr1 and Mlr2, showed that one of their cofactor proteins, NOL4, have several splice variants with different effects on the transactivation activities of Mlr proteins. These findings suggest that there is an additional layer of the regulation of Mblk-1 family proteins by cofactor splice variants and provide novel insights into our current understanding of the roles of the conserved transcription factor family. View Full-Text
Keywords: honeybee; transcription factor; Mblk-1; E93; MBR-1; Mlr1; LCoR; NOL4; transcription cofactor; splice variants honeybee; transcription factor; Mblk-1; E93; MBR-1; Mlr1; LCoR; NOL4; transcription cofactor; splice variants
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Takayanagi-Kiya, S.; Kiya, T.; Kunieda, T.; Kubo, T. Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals. Int. J. Mol. Sci. 2017, 18, 246.

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