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Int. J. Mol. Sci. 2017, 18(2), 244; doi:10.3390/ijms18020244

Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action

1,2,†
,
3,4,†
,
1,2
and
1,2,*
1
Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
2
Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
3
Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea
4
Department of Medical Science, School of Medicine, Pusan National University, Busan 49241, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 30 November 2016 / Revised: 15 January 2017 / Accepted: 18 January 2017 / Published: 25 January 2017
(This article belongs to the Special Issue Inflammatory Skin Conditions)
View Full-Text   |   Download PDF [1614 KB, uploaded 25 January 2017]   |  

Abstract

Inflammatory skin disorders that cause serious deterioration of the quality of life have become one of the major public concerns. Despite their significance, there is no fundamental cure to date. Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties which make them a promising tool for the treatment of various inflammatory diseases. Our recent preclinical and clinical studies have shown that MSCs can be successfully used for the treatment of atopic dermatitis (AD), one of the major inflammatory skin diseases. This observation along with similar reports from other groups revealed the efficacy and underlying mechanisms of MSCs in inflammatory dermatosis. In addition, it has been proposed that cell priming or gene transduction can be novel strategies for the development of next-generation high-efficacy MSCs for treating inflammatory skin diseases. We discuss here existing evidence that demonstrates the regulatory properties of MSCs on immune responses under inflammatory conditions. View Full-Text
Keywords: mesenchymal stem cells; stem cell therapy; immunomodulation; inflammatory skin diseases; atopic dermatitis; psoriasis mesenchymal stem cells; stem cell therapy; immunomodulation; inflammatory skin diseases; atopic dermatitis; psoriasis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shin, T.-H.; Kim, H.-S.; Choi, S.W.; Kang, K.-S. Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action. Int. J. Mol. Sci. 2017, 18, 244.

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