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Int. J. Mol. Sci. 2017, 18(12), 2747; doi:10.3390/ijms18122747

A Molecular Interpretation on the Different Penetration Enhancement Effect of Borneol and Menthol towards 5-Fluorouracil

1,2,†
,
1,†
,
1,2
,
1
,
1,2
,
1,2,* and 1,2,*
1
Beijing University of Chinese Medicine, No. 11 of North 3rd Ring East Road, Chaoyang District, Beijing 100029, China
2
Key Laboratory of TCM-Information Engineering of State Administration of TCM, No. 11 of North 3rd Ring East Road, Chaoyang District, Beijing 100029, China
These authors contributed equally to this study.
*
Authors to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 29 November 2017 / Accepted: 12 December 2017 / Published: 18 December 2017
(This article belongs to the Section Molecular Biophysics)
View Full-Text   |   Download PDF [2893 KB, uploaded 19 December 2017]   |  

Abstract

Borneol and menthol are terpenes that are widely used as penetration enhancers in transdermal drug delivery. To explore their penetration-enhancement effects on hydrophilic drugs, 5-fluorouracil (5-FU) was selected as a model drug. An approach that combined in vitro permeation studies and coarse-grained molecular dynamics was used to investigate their penetration-enhancement effect on 5-FU. The results showed that although both borneol and menthol imparted penetration-enhancement effects on 5-FU, these differed in terms of their mechanism, which may account for the observed variations in penetration-enhancement effects. The main mechanism of action of menthol involves the disruption of the stratum corneum (SC) bilayer, whereas borneol involves multiple mechanisms, including the disruption of the SC bilayer, increasing the diffusion coefficient of 5-FU, and inducing the formation of transient pores. The findings of the present study improve our understanding of the molecular mechanism that is underlying 5-FU penetration-enhancement by borneol and menthol, which may be utilized in future investigations and applications. View Full-Text
Keywords: penetration enhancement; molecular mechanism; coarse-grained molecular dynamics; menthol; borneol; 5-fluorouracil penetration enhancement; molecular mechanism; coarse-grained molecular dynamics; menthol; borneol; 5-fluorouracil
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Wang, R.; Wu, Z.; Yang, S.; Guo, S.; Dai, X.; Qiao, Y.; Shi, X. A Molecular Interpretation on the Different Penetration Enhancement Effect of Borneol and Menthol towards 5-Fluorouracil. Int. J. Mol. Sci. 2017, 18, 2747.

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