Next Article in Journal
Analysis and Prediction of Exon Skipping Events from RNA-Seq with Sequence Information Using Rotation Forest
Next Article in Special Issue
Pituitary Gonadotropins, Prolactin and Growth Hormone Differentially Regulate AQP1 Expression in the Porcine Ovarian Follicular Cells
Previous Article in Journal
The Consequences of Being in an Infectious Biofilm: Microenvironmental Conditions Governing Antibiotic Tolerance
Previous Article in Special Issue
Regulation of Aquaporin Functional Properties Mediated by the Antioxidant Effects of Natural Compounds
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(12), 2693; doi:10.3390/ijms18122693

The Role of Aquaporins in Ocular Lens Homeostasis

Department of Biochemistry, Vanderbilt University, Nashville, TN 37240, USA
Department of Physiology, School of Medical Sciences, New Zealand National Eye Centre, University of Auckland, Auckland 1023, New Zealand
School of Optometry and Vison Sciences, New Zealand National Eye Centre, University of Auckland, Auckland 1023, New Zealand
Author to whom correspondence should be addressed.
Received: 10 November 2017 / Revised: 8 December 2017 / Accepted: 8 December 2017 / Published: 12 December 2017
(This article belongs to the Special Issue Aquaporins: Water Channels Essential for Living Organisms)
View Full-Text   |   Download PDF [1794 KB, uploaded 12 December 2017]   |  


Abstract: Aquaporins (AQPs), by playing essential roles in the maintenance of ocular lens homeostasis, contribute to the establishment and maintenance of the overall optical properties of the lens over many decades of life. Three aquaporins, AQP0, AQP1 and AQP5, each with distinctly different functional properties, are abundantly and differentially expressed in the different regions of the ocular lens. Furthermore, the diversity of AQP functionality is increased in the absence of protein turnover by age-related modifications to lens AQPs that are proposed to alter AQP function in the different regions of the lens. These regional differences in AQP functionality are proposed to contribute to the generation and directionality of the lens internal microcirculation; a system of circulating ionic and fluid fluxes that delivers nutrients to and removes wastes from the lens faster than could be achieved by passive diffusion alone. In this review, we present how regional differences in lens AQP isoforms potentially contribute to this microcirculation system by highlighting current areas of investigation and emphasizing areas where future work is required. View Full-Text
Keywords: microcirculation; hydrostatic pressure; regulation; post-translational modification microcirculation; hydrostatic pressure; regulation; post-translational modification

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Schey, K.L.; Petrova, R.S.; Gletten, R.B.; Donaldson, P.J. The Role of Aquaporins in Ocular Lens Homeostasis. Int. J. Mol. Sci. 2017, 18, 2693.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top