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Int. J. Mol. Sci. 2017, 18(12), 2654; https://doi.org/10.3390/ijms18122654

RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection

1
Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, 69007 Lyon, France
2
Virologie et Pathologie Humaine—VirPath Team, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, 69008 Lyon, France
These authors contributed equally to this work.
Current Address: Center of Excellence for Tropical Infectious Diseases, Medical Diagnostic Discovery Department (MD3), bioMérieux, 20000-000 Rio de Janeiro, Brazil.
*
Author to whom correspondence should be addressed.
Received: 4 October 2017 / Revised: 3 December 2017 / Accepted: 4 December 2017 / Published: 7 December 2017
(This article belongs to the Special Issue Molecular Mechanism of Infectious Disease)
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Abstract

Respiratory syncytial virus (RSV), a major etiologic agent of acute lower respiratory infection constitutes the most important cause of death in young children worldwide. Viral/bacterial mixed infections are related to severity of respiratory inflammatory diseases, but the underlying mechanisms remain poorly understood. We have previously investigated the intracellular mechanisms that mediate the immune response in the context of influenza virus/Streptococcus pneumoniae (Sp) co-infection using a model of human monocyte-derived macrophages (MDMs). Here, we set up and characterized a similar model of MDMs to investigate different scenarios of RSV infection and co-infection with Sp. Our results suggest that Sp contributes to a faster and possibly higher level of CXCL10/IP-10 expression induced by RSV infection in human MDMs. View Full-Text
Keywords: respiratory syncytial virus (RSV); Streptococcus pneumoniae (Sp); macrophages; co-infection; acute lower respiratory infection respiratory syncytial virus (RSV); Streptococcus pneumoniae (Sp); macrophages; co-infection; acute lower respiratory infection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Machado, D.; Hoffmann, J.; Moroso, M.; Rosa-Calatrava, M.; Endtz, H.; Terrier, O.; Paranhos-Baccalà, G. RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection. Int. J. Mol. Sci. 2017, 18, 2654.

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