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Int. J. Mol. Sci. 2017, 18(12), 2640; doi:10.3390/ijms18122640

An Updated View of Translocator Protein (TSPO)

1
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, Italy
2
Department of Chemistry, University of Bari “Aldo Moro”, 70125 Bari, Italy
*
Authors to whom correspondence should be addressed.
Received: 13 November 2017 / Revised: 13 November 2017 / Accepted: 4 December 2017 / Published: 6 December 2017
(This article belongs to the Special Issue Translocator Protein (TSPO))
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Abstract

Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, including cholesterol transport, steroid hormone synthesis, mitochondrial respiration, permeability transition pore opening, apoptosis, and cell proliferation. Thus, TSPO has become an extremely attractive subcellular target for the early detection of disease states that involve the overexpression of this protein and the selective mitochondrial drug delivery. This special issue was programmed with the aim of summarizing the latest findings about the role of TSPO in eukaryotic cells and as a potential subcellular target of diagnostics or therapeutics. A total of 9 papers have been accepted for publication in this issue, in particular, 2 reviews and 7 primary data manuscripts, overall describing the main advances in this field. View Full-Text
Keywords: translocator protein (TSPO); neuroinflammation; steroidogenesis; subcellular targeting translocator protein (TSPO); neuroinflammation; steroidogenesis; subcellular targeting
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Denora, N.; Natile, G. An Updated View of Translocator Protein (TSPO). Int. J. Mol. Sci. 2017, 18, 2640.

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