Next Article in Journal
Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P1 Receptor Modulator in Healthy Subjects
Next Article in Special Issue
Recent Advances in the Role of SLC39A/ZIP Zinc Transporters In Vivo
Previous Article in Journal
Adverse Intrauterine Environment and Cardiac miRNA Expression
Previous Article in Special Issue
Report of the International Society for Zinc Biology 5th Meeting, in Collaboration with Zinc-Net (COST Action TD1304)—UCLan Campus, Pyla, Cyprus
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessDiscussion
Int. J. Mol. Sci. 2017, 18(12), 2631; https://doi.org/10.3390/ijms18122631

Pan-Domain Analysis of ZIP Zinc Transporters

1
Aberdeen Fungal Group, Medical Research Council Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
2
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
*
Author to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 1 December 2017 / Accepted: 1 December 2017 / Published: 6 December 2017
(This article belongs to the Special Issue Zinc Signaling in Physiology and Pathogenesis)
View Full-Text   |   Download PDF [1420 KB, uploaded 6 December 2017]   |  

Abstract

The ZIP (Zrt/Irt-like protein) family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution, or their origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal, and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers, (ii) a fungal-specific group of zinc importers having genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal, and eukaryotic phyla. View Full-Text
Keywords: ZIP; zinc; transport; transporter; evolution; pathogenic fungi; Candida albicans ZIP; zinc; transport; transporter; evolution; pathogenic fungi; Candida albicans
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Share & Cite This Article

MDPI and ACS Style

Lehtovirta-Morley, L.E.; Alsarraf, M.; Wilson, D. Pan-Domain Analysis of ZIP Zinc Transporters. Int. J. Mol. Sci. 2017, 18, 2631.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top