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Int. J. Mol. Sci. 2017, 18(12), 2540; https://doi.org/10.3390/ijms18122540

The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint

1
Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China
2
Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China
3
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350112, Fujian, China
*
Authors to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 17 November 2017 / Accepted: 18 November 2017 / Published: 27 November 2017
(This article belongs to the Special Issue Targeting Cancer through RNA Biology)
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Abstract

Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that altered expression of microRNAs play a pivotal role in immune checkpoint and various cellular processes in cancer. In this review, we focused on the latest progress about microRNAs research which involves the regulation of PD-1/PD-L1 immune checkpoint. View Full-Text
Keywords: programmed death-ligand 1 (PD-L1); programmed death 1(PD-1); microRNAs; immune checkpoint programmed death-ligand 1 (PD-L1); programmed death 1(PD-1); microRNAs; immune checkpoint
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Wang, Q.; Lin, W.; Tang, X.; Li, S.; Guo, L.; Lin, Y.; Kwok, H.F. The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint. Int. J. Mol. Sci. 2017, 18, 2540.

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