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Int. J. Mol. Sci. 2017, 18(12), 2526; doi:10.3390/ijms18122526

The Genetic Basis of Psoriasis

Department of Medical and Molecular Genetics, School of Basic and Biomedical Sciences, King’s College London, London SE1 9RT, UK
Received: 21 October 2017 / Revised: 21 November 2017 / Accepted: 22 November 2017 / Published: 25 November 2017
(This article belongs to the Special Issue Psoriasis)
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Abstract

Psoriasis is widely regarded as a multifactorial condition which is caused by the interaction between inherited susceptibility alleles and environmental triggers. In the last decade, technological advances have enabled substantial progress in the understanding of disease genetics. Genome-wide association studies have identified more than 60 disease susceptibility regions, highlighting the pathogenic involvement of genes related to Th17 cell activation. This pathway has now been targeted by a new generation of biologics that have shown great efficacy in clinical trials. At the same time, the study of rare variants of psoriasis has identified interleukin (IL)-36 cytokines as important amplifiers of Th17 signaling and promising targets for therapeutic intervention. Here, we review these exciting discoveries, which highlight the translational potential of genetic studies. View Full-Text
Keywords: psoriasis; genome-wide association studies; genome-wide association studies, GWAS; Th17 activation; IL-36 psoriasis; genome-wide association studies; genome-wide association studies, GWAS; Th17 activation; IL-36
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Capon, F. The Genetic Basis of Psoriasis. Int. J. Mol. Sci. 2017, 18, 2526.

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