The Genetic Basis of Psoriasis
AbstractPsoriasis is widely regarded as a multifactorial condition which is caused by the interaction between inherited susceptibility alleles and environmental triggers. In the last decade, technological advances have enabled substantial progress in the understanding of disease genetics. Genome-wide association studies have identified more than 60 disease susceptibility regions, highlighting the pathogenic involvement of genes related to Th17 cell activation. This pathway has now been targeted by a new generation of biologics that have shown great efficacy in clinical trials. At the same time, the study of rare variants of psoriasis has identified interleukin (IL)-36 cytokines as important amplifiers of Th17 signaling and promising targets for therapeutic intervention. Here, we review these exciting discoveries, which highlight the translational potential of genetic studies. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Capon, F. The Genetic Basis of Psoriasis. Int. J. Mol. Sci. 2017, 18, 2526.
Capon F. The Genetic Basis of Psoriasis. International Journal of Molecular Sciences. 2017; 18(12):2526.Chicago/Turabian Style
Capon, Francesca. 2017. "The Genetic Basis of Psoriasis." Int. J. Mol. Sci. 18, no. 12: 2526.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.