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Int. J. Mol. Sci. 2017, 18(11), 2365; https://doi.org/10.3390/ijms18112365

Metabolic Dysfunction and Oxidative Stress in Epilepsy

Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA
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Received: 27 September 2017 / Revised: 27 October 2017 / Accepted: 30 October 2017 / Published: 8 November 2017
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Abstract

The epilepsies are a heterogeneous group of disorders characterized by the propensity to experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the underlying mechanisms of seizure initiation, seizure propagation, and comorbid conditions are incompletely understood. Metabolic changes including the production of reactive species are known to result from prolonged seizures and may also contribute to epilepsy development. In this review, we focus on the evidence that metabolic and redox disruption is both cause and consequence of epileptic seizures. Additionally, we discuss the promise of targeting redox processes as a therapeutic option in epilepsy. View Full-Text
Keywords: mitochondria; reactive oxygen species; seizures mitochondria; reactive oxygen species; seizures
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pearson-Smith, J.N.; Patel, M. Metabolic Dysfunction and Oxidative Stress in Epilepsy. Int. J. Mol. Sci. 2017, 18, 2365.

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