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Int. J. Mol. Sci. 2017, 18(11), 2325; doi:10.3390/ijms18112325

Estrogen Effects on Wound Healing

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan
Institute of BioMedical Informatics, National Yang-Ming University, Taipei 112, Taiwan
Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan
Department of Nursing, National Yang-Ming University, Taipei 112, Taiwan
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung County 900, Taiwan
Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 30 October 2017 / Accepted: 2 November 2017 / Published: 3 November 2017
(This article belongs to the Special Issue Recent Advances in Scar Biology)
View Full-Text   |   Download PDF [246 KB, uploaded 3 November 2017]   |  


Wound healing is a physiological process, involving three successive and overlapping phases—hemostasis/inflammation, proliferation, and remodeling—to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing. View Full-Text
Keywords: estrogen; estrogen receptor; wound healing estrogen; estrogen receptor; wound healing

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Horng, H.-C.; Chang, W.-H.; Yeh, C.-C.; Huang, B.-S.; Chang, C.-P.; Chen, Y.-J.; Tsui, K.-H.; Wang, P.-H. Estrogen Effects on Wound Healing. Int. J. Mol. Sci. 2017, 18, 2325.

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