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Int. J. Mol. Sci. 2017, 18(11), 2264; https://doi.org/10.3390/ijms18112264

Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy

1
Department of Cell Biology, Genetics and Physiology, University of Málaga, IBIMA, 29071 Málaga, Spain
2
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, (CIBER-BBN), 29071 Málaga, Spain
3
Fundación de Investigación Oftalmológica, 33012 Oviedo, Spain
4
Laboratory of Bioingeneering and Tissue Regeneration, Andalusian Center for Nanomedicine and Biotechnology-BIONAND, 29590 Málaga, Spain
*
Author to whom correspondence should be addressed.
Received: 24 July 2017 / Revised: 9 October 2017 / Accepted: 28 October 2017 / Published: 28 October 2017
(This article belongs to the Special Issue Dry Eye and Ocular Surface Disorders)
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Abstract

Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is symptomatic, mainly based on the control of lubrication and inflammation, with significant limitations. Therefore, the latest research is focused on the development of new biological strategies, with the aim of regenerating affected tissues, or at least restricting the progression of the disease, reducing scar tissue, and maintaining corneal transparency. Therapies range from growth factors and cytokines to the use of different cell sources, in particular mesenchymal stem cells, due to their multipotentiality, trophic, and immunomodulatory properties. We will review the state of the art and the latest advances and results of these promising treatments in this pathology. View Full-Text
Keywords: mesenchymal stem cell; allogenic cell therapy; growth factor; lacrimal gland; dry eye; keratoconjunctivitis sicca; regenerative medicine mesenchymal stem cell; allogenic cell therapy; growth factor; lacrimal gland; dry eye; keratoconjunctivitis sicca; regenerative medicine
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Villatoro, A.J.; Fernández, V.; Claros, S.; Alcoholado, C.; Cifuentes, M.; Merayo-Lloves, J.; Andrades, J.A.; Becerra, J. Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy. Int. J. Mol. Sci. 2017, 18, 2264.

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