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Int. J. Mol. Sci. 2017, 18(11), 2236; doi:10.3390/ijms18112236

Preparation and Characterization of Resorbable Bacterial Cellulose Membranes Treated by Electron Beam Irradiation for Guided Bone Regeneration

1
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do 56212, Korea
2
Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea
3
Department of Prosthodontics, In-Je University Haeundae Paik Hospital, Busan 48108, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 September 2017 / Revised: 16 October 2017 / Accepted: 18 October 2017 / Published: 25 October 2017
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering 2017)
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Abstract

Bacterial cellulose (BC) is an excellent biomaterial with many medical applications. In this study, resorbable BC membranes were prepared for guided bone regeneration (GBR) using an irradiation technique for applications in the dental field. Electron beam irradiation (EI) increases biodegradation by severing the glucose bonds of BC. BC membranes irradiated at 100 kGy or 300 kGy were used to determine optimal electron beam doses. Electron beam irradiated BC membranes (EI-BCMs) were evaluated by scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, thermal gravimetric analysis (TGA), and using wet tensile strength measurements. In addition, in vitro cell studies were conducted in order to confirm the cytocompatibility of EI-BCMs. Cell viabilities of NIH3T3 cells on 100k and 300k EI-BCMs (100 kGy and 300 kGy irradiated BC membranes) were significantly greater than on NI-BCMs after 3 and 7 days (p < 0.05). Bone regeneration by EI-BCMs and their biodegradabilities were also evaluated using in vivo rat calvarial defect models for 4 and 8 weeks. Histometric results showed 100k EI-BCMs exhibited significantly larger new bone area (NBA; %) than 300k EI-BCMs at 8 weeks after implantation (p < 0.05). Mechanical, chemical, and biological analyses showed EI-BCMs effectively interacted with cells and promoted bone regeneration. View Full-Text
Keywords: bacterial cellulose membrane; guided bone regeneration; electron beam irradiation; resorbable barrier membrane; optimal radiation dose bacterial cellulose membrane; guided bone regeneration; electron beam irradiation; resorbable barrier membrane; optimal radiation dose
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

An, S.-J.; Lee, S.-H.; Huh, J.-B.; Jeong, S.I.; Park, J.-S.; Gwon, H.-J.; Kang, E.-S.; Jeong, C.-M.; Lim, Y.-M. Preparation and Characterization of Resorbable Bacterial Cellulose Membranes Treated by Electron Beam Irradiation for Guided Bone Regeneration. Int. J. Mol. Sci. 2017, 18, 2236.

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