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Int. J. Mol. Sci. 2017, 18(10), 2207; doi:10.3390/ijms18102207

Tubulin Post-Translational Modifications and Microtubule Dynamics

Laboratory of Cytoskeleton and Cilia Biology, Department of Cell Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Str., 02-093 Warsaw, Poland
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Received: 1 September 2017 / Revised: 12 October 2017 / Accepted: 19 October 2017 / Published: 21 October 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Microtubules are hollow tube-like polymeric structures composed of α,β-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell division. Moreover, microtubule doublets or triplets form a scaffold of a cilium, centriole and basal body, respectively. To perform such diverse functions microtubules have to differ in their properties. Post-translational modifications are one of the factors that affect the properties of the tubulin polymer. Here we focus on the direct and indirect effects of post-translational modifications of tubulin on microtubule dynamics. View Full-Text
Keywords: microtubule dynamics; post-translational modifications; acetylation; glutamylation; glycylation; methylation; phosphorylation; polyamination microtubule dynamics; post-translational modifications; acetylation; glutamylation; glycylation; methylation; phosphorylation; polyamination
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Wloga, D.; Joachimiak, E.; Fabczak, H. Tubulin Post-Translational Modifications and Microtubule Dynamics. Int. J. Mol. Sci. 2017, 18, 2207.

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