Next Article in Journal
Towards Better Understanding of Pea Seed Dormancy Using Laser Desorption/Ionization Mass Spectrometry
Next Article in Special Issue
Bioactivity of Olive Oil Phenols in Neuroprotection
Previous Article in Journal
Antioxidant Defence, Oxidative Stress and Oxidative Damage in Saliva, Plasma and Erythrocytes of Dementia Patients. Can Salivary AGE be a Marker of Dementia?
Previous Article in Special Issue
Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(10), 2190; https://doi.org/10.3390/ijms18102190

Neuroprotective Surgical Strategies in Parkinson’s Disease: Role of Preclinical Data

1
University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000 Grenoble, France
2
Department of Anatomy, University of Sydney; Sydney Medical School, Sydney NSW 2006, Australia
*
Author to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 10 October 2017 / Accepted: 13 October 2017 / Published: 20 October 2017
(This article belongs to the Special Issue Neuroprotective Strategies 2017)
View Full-Text   |   Download PDF [628 KB, uploaded 20 October 2017]   |  

Abstract

Although there have been many pharmacological agents considered to be neuroprotective therapy in Parkinson’s disease (PD) patients, neurosurgical approaches aimed to neuroprotect or restore the degenerative nigrostriatal system have rarely been the focus of in depth reviews. Here, we explore the neuroprotective strategies involving invasive surgical approaches (NSI) using neurotoxic models 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), which have led to clinical trials. We focus on several NSI approaches, namely deep brain stimulation of the subthalamic nucleus, glial neurotrophic derived factor (GDNF) administration and cell grafting methods. Although most of these interventions have produced positive results in preclinical animal models, either from behavioral or histological studies, they have generally failed to pass randomized clinical trials to validate each approach. We argue that NSI are promising approaches for neurorestoration in PD, but preclinical studies should be planned carefully in order not only to detect benefits but also to detect potential adverse effects. Further, clinical trials should be designed to be able to detect and disentangle neuroprotection from symptomatic effects. In summary, our review study evaluates the pertinence of preclinical models to study NSI for PD and how this affects their efficacy when translated into clinical trials. View Full-Text
Keywords: neuroprotection; Parkinson disease; surgery; cell grafts; glial neurotrophic derived factor; deep brain stimulation neuroprotection; Parkinson disease; surgery; cell grafts; glial neurotrophic derived factor; deep brain stimulation
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Torres, N.; Molet, J.; Moro, C.; Mitrofanis, J.; Benabid, A.L. Neuroprotective Surgical Strategies in Parkinson’s Disease: Role of Preclinical Data. Int. J. Mol. Sci. 2017, 18, 2190.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top