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Int. J. Mol. Sci. 2017, 18(10), 2072; doi:10.3390/ijms18102072

Splitting the “Unsplittable”: Dissecting Resident and Infiltrating Macrophages in Experimental Autoimmune Encephalomyelitis

1
Institute of Anatomy and Cell Biology, University of Würzburg, D-97070 Würzburg, Germany
2
Institute of Anatomy and Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg, D-91054 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Received: 3 September 2017 / Revised: 23 September 2017 / Accepted: 25 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue Advances in Multiple Sclerosis 2017)
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Abstract

Macrophages predominate the inflammatory landscape within multiple sclerosis (MS) lesions, not only regarding cellularity but also with respect to the diverse functions this cell fraction provides during disease progression and remission. Researchers have been well aware of the fact that the macrophage pool during central nervous system (CNS) autoimmunity consists of a mixture of myeloid cells. Yet, separating these populations to define their unique contribution to disease pathology has long been challenging due to their similar marker expression. Sophisticated lineage tracing approaches as well as comprehensive transcriptome analysis have elevated our insight into macrophage biology to a new level enabling scientists to dissect the roles of resident (microglia and non-parenchymal macrophages) and infiltrating macrophages with unprecedented precision. To do so in an accurate way, researchers have to know their toolbox, which has been filled with diverse, discriminating approaches from decades of studying neuroinflammation in animal models. Every method has its own strengths and weaknesses, which will be addressed in this review. The focus will be on tools to manipulate and/or identify different macrophage subgroups within the injured murine CNS. View Full-Text
Keywords: CNS; distinction; experimental autoimmune encephalomyelitis; inflammation; macrophages; markers; microglia; monocytes CNS; distinction; experimental autoimmune encephalomyelitis; inflammation; macrophages; markers; microglia; monocytes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Koeniger, T.; Kuerten, S. Splitting the “Unsplittable”: Dissecting Resident and Infiltrating Macrophages in Experimental Autoimmune Encephalomyelitis. Int. J. Mol. Sci. 2017, 18, 2072.

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