The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search
AbstractNematodes are a very diverse phylum that has adapted to nearly every ecosystem. They have developed specialized lifestyles, dividing the phylum into free-living, animal, and plant parasitic species. Their sheer abundance in numbers and presence in nearly every ecosystem make them the most prevalent animals on earth. In this research nematode-specific profiles were designed to retrieve predicted lectin-like domains from the sequence data of nematode genomes and transcriptomes. Lectins are carbohydrate-binding proteins that play numerous roles inside and outside the cell depending on their sugar specificity and associated protein domains. The sugar-binding properties of the retrieved lectin-like proteins were predicted in silico. Although most research has focused on C-type lectin-like, galectin-like, and calreticulin-like proteins in nematodes, we show that the lectin-like repertoire in nematodes is far more diverse. We focused on C-type lectins, which are abundantly present in all investigated nematode species, but seem to be far more abundant in free-living species. Although C-type lectin-like proteins are omnipresent in nematodes, we have shown that only a small part possesses the residues that are thought to be essential for carbohydrate binding. Curiously, hevein, a typical plant lectin domain not reported in animals before, was found in some nematode species. View Full-Text
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Bauters, L.; Naalden, D.; Gheysen, G. The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search. Int. J. Mol. Sci. 2017, 18, 91.
Bauters L, Naalden D, Gheysen G. The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search. International Journal of Molecular Sciences. 2017; 18(1):91.Chicago/Turabian Style
Bauters, Lander; Naalden, Diana; Gheysen, Godelieve. 2017. "The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search." Int. J. Mol. Sci. 18, no. 1: 91.
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