Next Article in Journal
Detection of Ribosomal DNA Sequence Polymorphisms in the Protist Plasmodiophora brassicae for the Identification of Geographical Isolates
Next Article in Special Issue
Anti-Neuroblastoma Properties of a Recombinant Sunflower Lectin
Previous Article in Journal
Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(1), 91; doi:10.3390/ijms18010091

The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search

Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, 9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Cheorl-Ho Kim
Received: 18 November 2016 / Revised: 20 December 2016 / Accepted: 28 December 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Plant Lectins: From Model Species to Crop Plants)
View Full-Text   |   Download PDF [1399 KB, uploaded 4 January 2017]   |  

Abstract

Nematodes are a very diverse phylum that has adapted to nearly every ecosystem. They have developed specialized lifestyles, dividing the phylum into free-living, animal, and plant parasitic species. Their sheer abundance in numbers and presence in nearly every ecosystem make them the most prevalent animals on earth. In this research nematode-specific profiles were designed to retrieve predicted lectin-like domains from the sequence data of nematode genomes and transcriptomes. Lectins are carbohydrate-binding proteins that play numerous roles inside and outside the cell depending on their sugar specificity and associated protein domains. The sugar-binding properties of the retrieved lectin-like proteins were predicted in silico. Although most research has focused on C-type lectin-like, galectin-like, and calreticulin-like proteins in nematodes, we show that the lectin-like repertoire in nematodes is far more diverse. We focused on C-type lectins, which are abundantly present in all investigated nematode species, but seem to be far more abundant in free-living species. Although C-type lectin-like proteins are omnipresent in nematodes, we have shown that only a small part possesses the residues that are thought to be essential for carbohydrate binding. Curiously, hevein, a typical plant lectin domain not reported in animals before, was found in some nematode species. View Full-Text
Keywords: nematode; C-type lectin; hevein; bioinformatic analysis nematode; C-type lectin; hevein; bioinformatic analysis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bauters, L.; Naalden, D.; Gheysen, G. The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search. Int. J. Mol. Sci. 2017, 18, 91.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top