Lysyl Oxidase and the Tumor Microenvironment
AbstractThe lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus maintaining the rigidity and structural stability of the extracellular matrix (ECM). Aberrant expression or activation of LOX alters the cellular microenvironment, leading to many diseases, including atherosclerosis, tissue fibrosis, and cancer. Recently, a number of studies have shown that LOX is overexpressed in most cancers and that it is involved in the regulation of tumor progression and metastasis. In contrast, a few reports have also indicated the tumor-suppressing role of LOX. In this short review, we discuss recent research on the correlations between LOX and cancer. Further, the role of LOX in tumor microenvironment remodeling, tumorigenesis, and metastasis and the underlying mechanisms have also been elucidated. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Wang, T.-H.; Hsia, S.-M.; Shieh, T.-M. Lysyl Oxidase and the Tumor Microenvironment. Int. J. Mol. Sci. 2017, 18, 62.
Wang T-H, Hsia S-M, Shieh T-M. Lysyl Oxidase and the Tumor Microenvironment. International Journal of Molecular Sciences. 2017; 18(1):62.Chicago/Turabian Style
Wang, Tong-Hong; Hsia, Shih-Min; Shieh, Tzong-Ming. 2017. "Lysyl Oxidase and the Tumor Microenvironment." Int. J. Mol. Sci. 18, no. 1: 62.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.