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Int. J. Mol. Sci. 2017, 18(1), 46; doi:10.3390/ijms18010046

Contribution of Gray and White Matter Abnormalities to Cognitive Impairment in Multiple Sclerosis

1
Department of Neurology, The General Hospital of Chinese People’s Liberation Army, Fuxing Road 28, Haidian District, Beijing 100853, China
2
Department of Neurology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, No. 20 East Yuhuangding Road, Yantai 264000, China
3
Department of Radiology, The General Hospital of Chinese People’s Liberation Army, Fuxing Road 28, Haidian District, Beijing 100853, China
4
Department of Neurology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, 240 W Thomas Rd., Ste 301, Phoenix, AZ 85013, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Received: 15 September 2016 / Revised: 10 December 2016 / Accepted: 16 December 2016 / Published: 27 December 2016
(This article belongs to the Special Issue Advances in Multiple Sclerosis 2016)
View Full-Text   |   Download PDF [2477 KB, uploaded 27 December 2016]   |  

Abstract

Patients with multiple sclerosis (MS) commonly exhibit cognitive impairments (CI). However, the neural mechanisms underlying CI remain unclear. The current study applied diffusion tensor imaging (DTI) and voxel-based morphometric (VBM) magnetic resonance imaging (MRI) techniques to evaluate differences in white matter (WM) integrity and gray matter (GM) volume between MS patients with CI and MS patients with cognitive preservation (CP). Neuropsychological assessment and MRI were obtained from 39 relapsing-remitting MS (RRMS) patients and 29 healthy controls (HCs). Patients were classified as CI or CP according to cognitive ability, and demographic characteristics and MRI images were compared. Compared with HCs, MS patients exhibited widespread damage in WM integrity, and GM loss in several regions. Compared with CP patients, CI patients exhibited more extensive WM impairments, particularly in the corpus callosum, cerebellar peduncle, corona radiata, optic radiation, superior longitudinal fasciculus, anterior limb of the internal capsule, and cingulate, as well as decreased GM volume in the bilateral caudate, left insula and right temporal lobe. MS patients with CI exhibited more significant structural abnormalities than those with CP. Widespread impairments of WM integrity and selective GM atrophy both appear to be associated with impaired cognition in RRMS. View Full-Text
Keywords: multiple sclerosis; cognitive impairment; diffusion tensor imaging; voxel-based morphology multiple sclerosis; cognitive impairment; diffusion tensor imaging; voxel-based morphology
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Zhang, X.; Zhang, F.; Huang, D.; Wu, L.; Ma, L.; Liu, H.; Zhao, Y.; Yu, S.; Shi, J. Contribution of Gray and White Matter Abnormalities to Cognitive Impairment in Multiple Sclerosis. Int. J. Mol. Sci. 2017, 18, 46.

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