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Int. J. Mol. Sci. 2017, 18(1), 42; doi:10.3390/ijms18010042

Lifetime Increased Risk of Adult Onset Atopic Dermatitis in Adolescent and Adult Patients with Food Allergy

1
Department of Food Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
2
Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
4
Department of Dermatology, National Yang Ming University College of Medicine, Taipei 112, Taiwan
5
Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
6
Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 4 October 2016 / Revised: 25 November 2016 / Accepted: 14 December 2016 / Published: 27 December 2016
(This article belongs to the Special Issue Inflammatory Skin Conditions)
View Full-Text   |   Download PDF [921 KB, uploaded 27 December 2016]   |  

Abstract

Food allergy can result in life-threatening anaphylaxis. Atopic dermatitis (AD) causes intense itching and impaired quality of life. Previous studies have shown that patients with classical early-onset AD tend to develop food allergy and that 10% of adults with food allergies have concomitant AD. However, it is not known whether late-onset food allergy leads to adult-onset AD, a recently recognized disease entity. Using an initial cohort of one-million subjects, this study retrospectively followed-up 2851 patients with food allergy (age > 12 years) for 14 years and compared them with 11,404 matched controls. While 2.8% (81) of the 2851 food allergy patients developed AD, only 2.0% (227) of the 11,404 controls developed AD. Multivariate regression analysis showed that food allergy patients were more likely to develop AD (adjusted hazard ratio = 2.49, p < 0.0001). Controls had a 1.99% risk of developing AD, while food allergy patients had a significantly higher risk (7.18% and 3.46% for patients with ≥3 and <3 food allergy claims, respectively) of developing adult-onset AD. This is the first study to describe the chronological and dose-dependent associations between food allergy in adolescence and the development of adult-onset AD. View Full-Text
Keywords: atopic dermatitis; food allergy; cohort study atopic dermatitis; food allergy; cohort study
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MDPI and ACS Style

Yu, H.-S.; Tu, H.-P.; Hong, C.-H.; Lee, C.-H. Lifetime Increased Risk of Adult Onset Atopic Dermatitis in Adolescent and Adult Patients with Food Allergy. Int. J. Mol. Sci. 2017, 18, 42.

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