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Int. J. Mol. Sci. 2017, 18(1), 23; doi:10.3390/ijms18010023

Cancer’s Achilles’ Heel: Apoptosis and Necroptosis to the Rescue

1
Department of Pediatrics, Texas Children’s Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX 77030, USA
2
Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Anthony Lemarié
Received: 7 November 2016 / Revised: 5 December 2016 / Accepted: 19 December 2016 / Published: 23 December 2016
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
View Full-Text   |   Download PDF [1640 KB, uploaded 23 December 2016]   |  

Abstract

Apoptosis, and the more recently discovered necroptosis, are two avenues of programmed cell death. Cancer cells survive by evading these two programs, driven by oncogenes and tumor suppressor genes. While traditional therapy using small molecular inhibitors and chemotherapy are continuously being utilized, a new and exciting approach is actively underway by identifying and using synergistic relationship between driver and rescue genes in a cancer cell. Through these synthetic lethal relationships, we are gaining tremendous insights into tumor vulnerabilities and specific molecular avenues for induction of programmed cell death. In this review, we briefly discuss the two cell death processes and cite examples of such synergistic manipulations for therapeutic purposes. View Full-Text
Keywords: apoptosis; necroptosis; necrosis; cancer; synergy; synthetic lethality; DNA damage; therapeutics apoptosis; necroptosis; necrosis; cancer; synergy; synthetic lethality; DNA damage; therapeutics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dasgupta, A.; Nomura, M.; Shuck, R.; Yustein, J. Cancer’s Achilles’ Heel: Apoptosis and Necroptosis to the Rescue. Int. J. Mol. Sci. 2017, 18, 23.

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