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Int. J. Mol. Sci. 2017, 18(1), 1; doi:10.3390/ijms18010001

CD11c+ CD8+ T Cells Reduce Renal Fibrosis Following Ureteric Obstruction by Inducing Fibroblast Apoptosis

1,2,†
,
3,†
,
2
,
2
,
2
and
1,4,*
1
College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China
2
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China
3
Department of Geriatrics, Tongji Hospital of Shanghai affiliated to Tongji University, Shanghai 20065, China
4
The Beijing Institute of Heart Lung and Blood Vessel Diseases, Chaoyang, Beijing 100029, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Anthony Lemarié
Received: 10 October 2016 / Revised: 5 December 2016 / Accepted: 11 December 2016 / Published: 22 December 2016
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
View Full-Text   |   Download PDF [4750 KB, uploaded 22 December 2016]   |  

Abstract

Tubulointerstitial fibrosis is a common consequence of various kidney diseases that lead to end-stage renal failure, and lymphocyte infiltration plays an important role in renal fibrosis. We previously found that depletion of cluster of differentiation 8+ (CD8+) T cells increases renal fibrosis following ureteric obstruction, and interferon-γ (IFN-γ)-expressing CD8+ T cells contribute to this process. CD8+ T cells are cytotoxic T cells; however, whether their cytotoxic effect reduces fibrosis remains unknown. This study showed that CD8+ T cells isolated from obstructed kidney showed mRNA expression of the cytotoxicity-related genes perforin 1, granzyme A, granzyme B, and FAS ligand; additionally, CD8 knockout significantly reduced the expression levels of these genes in obstructed kidney. Infiltrated CD8+ T cells were distributed around fibroblasts, and they are associated with fibroblast apoptosis in obstructed kidney. Moreover, CD11c+ CD8+ T cells expressed higher levels of the cytotoxicity-related genes than CD11c CD8+ T cells, and infiltrated CD11c+ CD8+ T cells in obstructed kidney could induce fibroblast death in vitro. Results indicated that induction of fibroblast apoptosis partly contributed to the effect of CD8+ T cells on reduction of renal fibrosis. Given that inflammatory cells are involved in fibrosis, our results suggest that kidney fibrosis is a multifactorial process involving different arms of the immune system. View Full-Text
Keywords: T cells; fibroblasts; fibrosis; inflammation; kidney T cells; fibroblasts; fibrosis; inflammation; kidney
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Wang, H.; Wang, J.; Bai, Y.; Li, J.; Li, L.; Dong, Y. CD11c+ CD8+ T Cells Reduce Renal Fibrosis Following Ureteric Obstruction by Inducing Fibroblast Apoptosis. Int. J. Mol. Sci. 2017, 18, 1.

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