Next Article in Journal
Histone Posttranslational Modifications of CD4+ T Cell in Autoimmune Diseases
Next Article in Special Issue
Analogs of Natural 3-Deoxyanthocyanins: O-Glucosides of the 4′,7-Dihydroxyflavylium Ion and the Deep Influence of Glycosidation on Color
Previous Article in Journal
Involvement of Ca2+ Signaling in the Synergistic Effects between Muscarinic Receptor Antagonists and β2-Adrenoceptor Agonists in Airway Smooth Muscle
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(9), 1588; doi:10.3390/ijms17091588

Anthocyanin Attenuates Doxorubicin-Induced Cardiomyotoxicity via Estrogen Receptor-α/β and Stabilizes HSF1 to Inhibit the IGF-IIR Apoptotic Pathway

1
Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan
2
Department of Obstetrics and Gynecology, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
3
Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan
4
Department of Nursing, Mei Ho University, Pingguang Road, Pingtung 91202, Taiwan
5
Section of Cardiology, Yuan Rung Hospital, Yuanlin 51045, Taiwan
6
Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan
7
Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan
8
Chinese Medicine Department, China Medical University Beigang Hospital, Taichung 40402, Taiwan
9
Department of Biotechnology, Bharathiar University, Coimbatore 641046, India
10
Institute of Oral Biology, National Yang-Ming University, Taipei 11221, Taiwan
11
Translation Research Core, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
12
Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan
13
Graduate Institute of Chinese Medical Science, China Medical University, Hsueh-Shih Road, Taichung 40402, Taiwan
14
Department of Health and Nutrition Biotechnology, Asia University, Taichung 40402, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Nuno Mateus and Iva Fernandes
Received: 24 June 2016 / Revised: 23 August 2016 / Accepted: 13 September 2016 / Published: 21 September 2016
(This article belongs to the Special Issue Anthocyanins)
View Full-Text   |   Download PDF [3166 KB, uploaded 21 September 2016]   |  

Abstract

Doxorubicin (Dox) is extensively used for chemotherapy in different types of cancer, but its use is limited to because of its cardiotoxicity. Our previous studies found that doxorubicin-induced insulin-like growth factor II receptor (IGF-IIR) accumulation causes cardiomyocytes apoptosis via down-regulation of HSF1 pathway. In these studies, we demonstrated a new mechanism through which anthocyanin protects cardiomyoblast cells against doxorubicin-induced injury. We found that anthocyanin decreased IGF-IIR expression via estrogen receptors and stabilized heat shock factor 1 (HSF1) to inhibit caspase 3 activation and apoptosis of cardiomyocytes. Therefore, the phytoestrogen from plants has been considered as another potential treatment for heart failure. It has been reported that the natural compound anthocyanin (ACN) has the ability to reduce the risk of cardiovascular disease (CVD). Here, we demonstrated that anthocyanin acts as a cardioprotective drug against doxorubicin-induced heart failure by attenuating cardiac apoptosis via estrogen receptors to stabilize HSF1 expression and down-regulated IGF-IIR-induced cardiomyocyte apoptosis. View Full-Text
Keywords: doxorubicin; anthocyanin; IGF-IIR signaling; apoptosis; estrogen receptors; cardiomyocyte doxorubicin; anthocyanin; IGF-IIR signaling; apoptosis; estrogen receptors; cardiomyocyte
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huang, P.-C.; Kuo, W.-W.; Shen, C.-Y.; Chen, Y.-F.; Lin, Y.-M.; Ho, T.-J.; Padma, V.V.; Lo, J.-F.; Huang, C.-Y.; Huang, C.-Y. Anthocyanin Attenuates Doxorubicin-Induced Cardiomyotoxicity via Estrogen Receptor-α/β and Stabilizes HSF1 to Inhibit the IGF-IIR Apoptotic Pathway. Int. J. Mol. Sci. 2016, 17, 1588.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top