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Int. J. Mol. Sci. 2016, 17(9), 1562; doi:10.3390/ijms17091562

Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition

1
Department of Dermatology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea
2
Department of Life Science, Sookmyung Women’s University, Seoul 04310, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 17 May 2016 / Revised: 23 August 2016 / Accepted: 7 September 2016 / Published: 15 September 2016
(This article belongs to the Special Issue Inflammatory Skin Conditions)
View Full-Text   |   Download PDF [1327 KB, uploaded 15 September 2016]   |  

Abstract

Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. We describe the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology. Understanding the molecular pathomechanisms of rosacea will likely aid toward better comprehending its complex pathogenesis. View Full-Text
Keywords: rosacea; genetic; triggering factor; immune defect; inflammation; neurovascular dysregulation rosacea; genetic; triggering factor; immune defect; inflammation; neurovascular dysregulation
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MDPI and ACS Style

Woo, Y.R.; Lim, J.H.; Cho, D.H.; Park, H.J. Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition. Int. J. Mol. Sci. 2016, 17, 1562.

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