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Int. J. Mol. Sci. 2016, 17(9), 1545; doi:10.3390/ijms17091545

Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus

1
Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, Kanagawa, Kawasaki 216-8511, Japan
2
Division of Gastroenterology, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Kanagawa, Yokohama 241-0811, Japan
3
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital, Kanagawa, Kawasaki 214-8525, Japan
4
Anzai Medical Company, Ltd., Tokyo 141-0033, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Amedeo Lonardo and Giovanni Targher
Received: 30 June 2016 / Revised: 1 September 2016 / Accepted: 8 September 2016 / Published: 14 September 2016
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
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Abstract

The progression of chronic liver disease differs by etiology. The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF). Xenon computed tomography (Xe-CT) was performed in 139 patients with NAFLD and 152 patients with CHC (including liver cirrhosis (LC)). The cutoff values for fibrosis markers were compared between NAFLD and CHC, and correlations between hepatic TBF and liver function tests were examined at each fibrosis stage. The cutoff values for detection of the advanced fibrosis stage were lower in NAFLD than in CHC. Although portal venous TBF (PVTBF) correlated with liver function tests, PVTBF in initial LC caused by nonalcoholic steatohepatitis (NASH-LC) was significantly lower than that in hepatitis C virus (C-LC) (p = 0.014). Conversely, the liver function tests in NASH-LC were higher than those in C-LC (p < 0.05). It is important to recognize the difference between NAFLD and CHC. We concluded that changes in hepatic blood flow occurred during the earliest stage of hepatic fibrosis in patients with NAFLD; therefore, patients with NAFLD need to be followed carefully. View Full-Text
Keywords: nonalcoholic steatohepatitis; chronic hepatitis C; liver function; hepatic hemodynamics; WFA+-M2BP nonalcoholic steatohepatitis; chronic hepatitis C; liver function; hepatic hemodynamics; WFA+-M2BP
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Shigefuku, R.; Takahashi, H.; Nakano, H.; Watanabe, T.; Matsunaga, K.; Matsumoto, N.; Kato, M.; Morita, R.; Michikawa, Y.; Tamura, T.; Hiraishi, T.; Hattori, N.; Noguchi, Y.; Nakahara, K.; Ikeda, H.; Ishii, T.; Okuse, C.; Sase, S.; Itoh, F.; Suzuki, M. Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus. Int. J. Mol. Sci. 2016, 17, 1545.

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