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Int. J. Mol. Sci. 2016, 17(9), 1500; doi:10.3390/ijms17091500

Impact of Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein in Patients with Hepatitis C Virus-Related Compensated Liver Cirrhosis

Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Hyogo 663-8501, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Tatsuo Kanda
Received: 2 August 2016 / Revised: 30 August 2016 / Accepted: 31 August 2016 / Published: 12 September 2016
(This article belongs to the Special Issue Hepatitis Virus Infection and Research)
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Abstract

We aimed to examine the effect of Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) level on survival comparing with other laboratory liver fibrosis markers in hepatitis C virus (HCV)-related compensated liver cirrhosis (LC) (n = 165). For assessing prognostic performance of continuous fibrosis markers, we adapted time-dependent receiver operating characteristics (ROC) curves for clinical outcome. In time-dependent ROC analysis, annual area under the ROCs (AUROCs) were plotted. We also calculated the total sum of AUROCs in all time-points (TAAT score) in each fibrosis marker. WFA+-M2BP value ranged from 0.66 cutoff index (COI) to 19.95 COI (median value, 5.29 COI). Using ROC analysis for survival, the optimal cutoff point for WFA+-M2BP was 6.15 COI (AUROC = 0.79348, sensitivity = 80.0%, specificity = 74.78%). The cumulative five-year survival rate in patients with WFA+-M2BP ≥ 6.15 COI (n = 69) was 43.99%, while that in patients with WFA+-M2BP < 6.15 COI (n = 96) was 88.40% (p < 0.0001). In the multivariate analysis, absence of hepatocellular carcinoma (p = 0.0008), WFA+-M2BP < 6.15 COI (p = 0.0132), achievement of sustained virological response (p < 0.0001) and des-γ-carboxy prothrombin < 41 mAU/mL (p = 0.0018) were significant favorable predictors linked to survival. In time-dependent ROC analysis in all cases, WFA+-M2BP had the highest TAAT score among liver fibrosis markers. In conclusion, WFA+-M2BP can be a useful predictor in HCV-related compensated LC. View Full-Text
Keywords: hepatitis C virus; liver cirrhosis; hepatocellular carcinoma; Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP); survival; time-dependent receiver operating characteristics (ROC) analysis hepatitis C virus; liver cirrhosis; hepatocellular carcinoma; Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP); survival; time-dependent receiver operating characteristics (ROC) analysis
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MDPI and ACS Style

Hasegawa, K.; Takata, R.; Nishikawa, H.; Enomoto, H.; Ishii, A.; Iwata, Y.; Miyamoto, Y.; Ishii, N.; Yuri, Y.; Nakano, C.; Nishimura, T.; Yoh, K.; Aizawa, N.; Sakai, Y.; Ikeda, N.; Takashima, T.; Iijima, H.; Nishiguchi, S. Impact of Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein in Patients with Hepatitis C Virus-Related Compensated Liver Cirrhosis. Int. J. Mol. Sci. 2016, 17, 1500.

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