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Int. J. Mol. Sci. 2016, 17(9), 1494; doi:10.3390/ijms17091494

Advances and Future Applications of Augmented Peripheral Nerve Regeneration

1
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
2
Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
3
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
4
Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
5
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Irmgard Tegeder
Received: 15 July 2016 / Revised: 30 August 2016 / Accepted: 30 August 2016 / Published: 7 September 2016
(This article belongs to the Special Issue Peripheral Nerve Regeneration: From Bench to Bedside)
View Full-Text   |   Download PDF [249 KB, uploaded 7 September 2016]   |  

Abstract

Peripheral nerve injuries remain a significant source of long lasting morbidity, disability, and economic costs. Much research continues to be performed in areas related to improving the surgical outcomes of peripheral nerve repair. In this review, the physiology of peripheral nerve regeneration and the multitude of efforts to improve surgical outcomes are discussed. Improvements in tissue engineering that have allowed for the use of synthetic conduits seeded with neurotrophic factors are highlighted. Selected pre-clinical and available clinical data using cell based methods such as Schwann cell, undifferentiated, and differentiated stem cell transplantation to guide and enhance peripheral nerve regeneration are presented. The limitations that still exist in the utility of neurotrophic factors and cell-based therapies are outlined. Strategies that are most promising for translation into the clinical arena are suggested. View Full-Text
Keywords: peripheral nerve; peripheral nerve regeneration; stem cells; neurotrophic factors; nerve conduits peripheral nerve; peripheral nerve regeneration; stem cells; neurotrophic factors; nerve conduits
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jones, S.; Eisenberg, H.M.; Jia, X. Advances and Future Applications of Augmented Peripheral Nerve Regeneration. Int. J. Mol. Sci. 2016, 17, 1494.

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