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Int. J. Mol. Sci. 2016, 17(8), 1312; doi:10.3390/ijms17081312

The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm

1
Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, 4811 Townsville, Australia
2
Department of Vascular and Endovascular Surgery, The Townsville Hospital, 4811 Townsville, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Shaker A. Mousa
Received: 18 July 2016 / Revised: 29 July 2016 / Accepted: 5 August 2016 / Published: 11 August 2016
(This article belongs to the Special Issue Vascular Biology and Therapeutics)
View Full-Text   |   Download PDF [2039 KB, uploaded 22 August 2016]   |  

Abstract

Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cell apoptosis, angiogenesis, oxidative stress and vascular remodeling are implicated in AAA pathogenesis. Kallistatin is a serine proteinase inhibitor, which has been shown to have a variety of functions, potentially relevant in AAA pathogenesis. Kallistatin has been reported to have inhibitory effects on tumor necrosis factor alpha (TNF-α) signaling induced oxidative stress and apoptosis. Kallistatin also inhibits vascular endothelial growth factor (VEGF) and Wnt canonical signaling, which promote inflammation, angiogenesis, and vascular remodeling in various pre-clinical experimental models. This review explores the potential protective role of kallistatin in AAA pathogenesis. View Full-Text
Keywords: kallistatin; serine proteinase inhibitors; abdominal aortic aneurysm; vascular remodelling; oxidative stress kallistatin; serine proteinase inhibitors; abdominal aortic aneurysm; vascular remodelling; oxidative stress
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Li, J.; Krishna, S.M.; Golledge, J. The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm. Int. J. Mol. Sci. 2016, 17, 1312.

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