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Int. J. Mol. Sci. 2016, 17(8), 1310; doi:10.3390/ijms17081310

Urinary Metabolic Phenotyping Reveals Differences in the Metabolic Status of Healthy and Inflammatory Bowel Disease (IBD) Children in Relation to Growth and Disease Activity

1
Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland
2
Division of Pediatric Gastroenterology, University of Lausanne, 1011 Lausanne, Switzerland
3
Nestlé Research Center, 1000 Lausanne, Switzerland
*
Authors to whom correspondence should be addressed.
Academic Editor: Ting-Li (Morgan) Han
Received: 22 June 2016 / Revised: 28 July 2016 / Accepted: 4 August 2016 / Published: 11 August 2016
(This article belongs to the Special Issue Metabolomic Technologies in Medicine)
View Full-Text   |   Download PDF [845 KB, uploaded 11 August 2016]   |  

Abstract

Background: Growth failure and delayed puberty are well known features of children and adolescents with inflammatory bowel disease (IBD), in addition to the chronic course of the disease. Urinary metabonomics was applied in order to better understand metabolic changes between healthy and IBD children. Methods: 21 Pediatric patients with IBD (mean age 14.8 years, 8 males) were enrolled from the Pediatric Gastroenterology Outpatient Clinic over two years. Clinical and biological data were collected at baseline, 6, and 12 months. 27 healthy children (mean age 12.9 years, 16 males) were assessed at baseline. Urine samples were collected at each visit and subjected to 1H Nuclear Magnetic Resonance (NMR) spectroscopy. Results: Using 1H NMR metabonomics, we determined that urine metabolic profiles of IBD children differ significantly from healthy controls. Metabolic differences include central energy metabolism, amino acid, and gut microbial metabolic pathways. The analysis described that combined urinary urea and phenylacetylglutamine—two readouts of nitrogen metabolism—may be relevant to monitor metabolic status in the course of disease. Conclusion: Non-invasive sampling of urine followed by metabonomic profiling can elucidate and monitor the metabolic status of children in relation to disease status. Further developments of omic-approaches in pediatric research might deliver novel nutritional and metabolic hypotheses. View Full-Text
Keywords: pediatric; metabolism; phenotype; growth; inflammatory bowel disease; Crohn’s disease; ulcerative colitis pediatric; metabolism; phenotype; growth; inflammatory bowel disease; Crohn’s disease; ulcerative colitis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Martin, F.-P.; Ezri, J.; Cominetti, O.; Da Silva, L.; Kussmann, M.; Godin, J.-P.; Nydegger, A. Urinary Metabolic Phenotyping Reveals Differences in the Metabolic Status of Healthy and Inflammatory Bowel Disease (IBD) Children in Relation to Growth and Disease Activity. Int. J. Mol. Sci. 2016, 17, 1310.

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