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Int. J. Mol. Sci. 2016, 17(8), 1307; doi:10.3390/ijms17081307

Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis

1
Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China
2
Department of Gynaecology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang, China
3
Key Laboratory of Reproductive Genetics, National Ministry of Education (Zhejiang University), Women’s Reproductive Healthy Laboratory of Zhejiang Province, Hangzhou 310058, Zhejiang, China
*
Author to whom correspondence should be addressed.
Academic Editor: Atsushi Matsuzawa
Received: 15 June 2016 / Revised: 2 August 2016 / Accepted: 3 August 2016 / Published: 10 August 2016
(This article belongs to the Special Issue Kinase Signal Transduction)
View Full-Text   |   Download PDF [2865 KB, uploaded 10 August 2016]   |  

Abstract

The ubiquitously expressed serum and glucocorticoid regulated kinase 1 (SGK1) is tightly regulated by osmotic and hormonal signals, including glucocorticoids and mineralocorticoids. Recently, SGK1 has been implicated as a signal hub for the regulation of sodium transport. SGK1 modulates the activities of multiple ion channels and carriers, such as epithelial sodium channel (ENaC), voltage-gated sodium channel (Nav1.5), sodium hydrogen exchangers 1 and 3 (NHE1 and NHE3), sodium-chloride symporter (NCC), and sodium-potassium-chloride cotransporter 2 (NKCC2); as well as the sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) and type A natriuretic peptide receptor (NPR-A). Accordingly, SGK1 is implicated in the physiology and pathophysiology of Na+ homeostasis. Here, we focus particularly on recent findings of SGK1’s involvement in Na+ transport in renal sodium reabsorption, hormone-stimulated salt appetite and fluid balance and discuss the abnormal SGK1-mediated Na+ reabsorption in hypertension, heart disease, edema with diabetes, and embryo implantation failure. View Full-Text
Keywords: serum and glucocorticoid regulated kinase 1 (SGK1); epithelial sodium channels; voltage-gated sodium channels; hypertension; edema; heart disease; embryo implantation serum and glucocorticoid regulated kinase 1 (SGK1); epithelial sodium channels; voltage-gated sodium channels; hypertension; edema; heart disease; embryo implantation
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MDPI and ACS Style

Lou, Y.; Zhang, F.; Luo, Y.; Wang, L.; Huang, S.; Jin, F. Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis. Int. J. Mol. Sci. 2016, 17, 1307.

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