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Int. J. Mol. Sci. 2016, 17(8), 1307; doi:10.3390/ijms17081307

Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis

Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China
Department of Gynaecology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang, China
Key Laboratory of Reproductive Genetics, National Ministry of Education (Zhejiang University), Women’s Reproductive Healthy Laboratory of Zhejiang Province, Hangzhou 310058, Zhejiang, China
Author to whom correspondence should be addressed.
Academic Editor: Atsushi Matsuzawa
Received: 15 June 2016 / Revised: 2 August 2016 / Accepted: 3 August 2016 / Published: 10 August 2016
(This article belongs to the Special Issue Kinase Signal Transduction)
View Full-Text   |   Download PDF [2865 KB, uploaded 10 August 2016]   |  


The ubiquitously expressed serum and glucocorticoid regulated kinase 1 (SGK1) is tightly regulated by osmotic and hormonal signals, including glucocorticoids and mineralocorticoids. Recently, SGK1 has been implicated as a signal hub for the regulation of sodium transport. SGK1 modulates the activities of multiple ion channels and carriers, such as epithelial sodium channel (ENaC), voltage-gated sodium channel (Nav1.5), sodium hydrogen exchangers 1 and 3 (NHE1 and NHE3), sodium-chloride symporter (NCC), and sodium-potassium-chloride cotransporter 2 (NKCC2); as well as the sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) and type A natriuretic peptide receptor (NPR-A). Accordingly, SGK1 is implicated in the physiology and pathophysiology of Na+ homeostasis. Here, we focus particularly on recent findings of SGK1’s involvement in Na+ transport in renal sodium reabsorption, hormone-stimulated salt appetite and fluid balance and discuss the abnormal SGK1-mediated Na+ reabsorption in hypertension, heart disease, edema with diabetes, and embryo implantation failure. View Full-Text
Keywords: serum and glucocorticoid regulated kinase 1 (SGK1); epithelial sodium channels; voltage-gated sodium channels; hypertension; edema; heart disease; embryo implantation serum and glucocorticoid regulated kinase 1 (SGK1); epithelial sodium channels; voltage-gated sodium channels; hypertension; edema; heart disease; embryo implantation

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lou, Y.; Zhang, F.; Luo, Y.; Wang, L.; Huang, S.; Jin, F. Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis. Int. J. Mol. Sci. 2016, 17, 1307.

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