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Int. J. Mol. Sci. 2016, 17(8), 1249; doi:10.3390/ijms17081249

Aquaporin-4 and Cerebrovascular Diseases

1
Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No. 12 Mid. Wulumuqi Road, Shanghai 200040, China
2
Department of Neurology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, No. 600 Yishan Road, Shanghai 200030, China
3
Department of Neurology, Jinshan Hospital, Fudan University, No. 1508 Longhang Road, Shanghai 201508, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 25 May 2016 / Revised: 20 July 2016 / Accepted: 26 July 2016 / Published: 11 August 2016
(This article belongs to the Special Issue Aquaporin)
View Full-Text   |   Download PDF [1717 KB, uploaded 11 August 2016]   |  

Abstract

Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema. Considering brain edema is an important pathophysiological change after stoke, AQP4 is destined to have close relation with cerebrovascular diseases. However, this relation is not limited to brain edema due to other biological effects elicited by AQP4. Till now, multiple studies have investigated roles of AQP4 in cerebrovascular diseases. This review focuses on expression of AQP4 and the effects of AQP4 on brain edema and neural cells injuries in cerebrovascular diseases including cerebral ischemia, intracerebral hemorrhage and subarachnoid hemorrhage. In the current review, we pay more attention to the studies of recent years directly from cerebrovascular diseases animal models or patients, especially those using AQP4 gene knockout mice. This review also elucidates the potential of AQP4as an excellent therapeutic target. View Full-Text
Keywords: aquaporin-4; cerebral ischemia; intracerebral hemorrhage; subarachnoid hemorrhage aquaporin-4; cerebral ischemia; intracerebral hemorrhage; subarachnoid hemorrhage
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MDPI and ACS Style

Chu, H.; Huang, C.; Ding, H.; Dong, J.; Gao, Z.; Yang, X.; Tang, Y.; Dong, Q. Aquaporin-4 and Cerebrovascular Diseases. Int. J. Mol. Sci. 2016, 17, 1249.

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