Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis
AbstractAtopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly understood, and the treatment of recalcitrant AD is still challenging. There is accumulating evidence for new gene polymorphisms related to the epidermal barrier function and innate and adaptive immunity in patients with AD. Newly-found T cells and dendritic cell subsets, cytokines, chemokines and signaling pathways have extended our understanding of the molecular pathomechanism underlying AD. Genetic changes caused by environmental factors have been shown to contribute to the pathogenesis of AD. We herein present a review of the genetics, epigenetics, barrier dysfunction and immunological abnormalities in AD with a focus on updated molecular biology. View Full-Text
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Kim, J.E.; Kim, J.S.; Cho, D.H.; Park, H.J. Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis. Int. J. Mol. Sci. 2016, 17, 1234.
Kim JE, Kim JS, Cho DH, Park HJ. Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis. International Journal of Molecular Sciences. 2016; 17(8):1234.Chicago/Turabian Style
Kim, Jung E.; Kim, Jong S.; Cho, Dae H.; Park, Hyun J. 2016. "Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis." Int. J. Mol. Sci. 17, no. 8: 1234.
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