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Int. J. Mol. Sci. 2016, 17(8), 1203; doi:10.3390/ijms17081203

Genome-Wide Identification and Characterization of Carboxypeptidase Genes in Silkworm (Bombyx mori)

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China
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Academic Editor: Kun Yan Zhu
Received: 10 May 2016 / Revised: 14 July 2016 / Accepted: 19 July 2016 / Published: 28 July 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The silkworm (Bombyx mori) is an economically-important insect that can secrete silk. Carboxypeptidases have been found in various metazoan species and play important roles in physiological and biochemical reactions. Here, we analyzed the silkworm genome database and characterized 48 carboxypeptidases, including 34 metal carboxypeptidases (BmMCP1BmMCP34) and 14 serine carboxypeptidases (BmSCP1BmSCP14), to better understand their diverse functions. Compared to other insects, our results indicated that carboxypeptidases from silkworm have more family members. These silkworm carboxypeptidases could be divided into four families: Peptidase_M2 carboxypeptidases, Peptidase_M14 carboxypeptidases, Peptidase_S10 carboxypeptidases and Peptidase_S28 carboxypeptidases. Microarray analysis showed that the carboxypeptidases had distinct expression patterns, whereas quantitative real-time PCR demonstrated that the expression level of 13 carboxypeptidases significantly decreased after starvation and restored after re-feeding. Overall, our study provides new insights into the functional and evolutionary features of silkworm carboxypeptidases. View Full-Text
Keywords: carboxypeptidase family; evolutionary analysis; expression pattern; starvation; Bombyx mori carboxypeptidase family; evolutionary analysis; expression pattern; starvation; Bombyx mori
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ye, J.; Li, Y.; Liu, H.-W.; Li, J.; Dong, Z.; Xia, Q.; Zhao, P. Genome-Wide Identification and Characterization of Carboxypeptidase Genes in Silkworm (Bombyx mori). Int. J. Mol. Sci. 2016, 17, 1203.

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