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Int. J. Mol. Sci. 2016, 17(7), 1096; doi:10.3390/ijms17071096

Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal
Instituto de Fisiología Experimental-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas-Universidad Nacional de Rosario, 531 S2002LRK Rosario, Santa Fe, Argentina
Department of Biosciences, Biotechnologies and Biopharnaceutics, University of Bari “Aldo Moro”, 70125 Bari, Italy
CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal
Authors to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 4 June 2016 / Revised: 22 June 2016 / Accepted: 4 July 2016 / Published: 9 July 2016
(This article belongs to the Special Issue Aquaporin)
View Full-Text   |   Download PDF [2867 KB, uploaded 9 July 2016]   |  


Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regarding the expression and modulation, as well as physiological and pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining energy homeostasis in these cells and have a major role in the metabolic cooperation established in the testicular tissue. Altogether, this information represents the mainstay of current and future investigation in an expanding field. View Full-Text
Keywords: mitochondria; reactive oxygen species (ROS); metabolic homeostasis; bile formation; Non-Alcoholic Fatty Liver Disease (NAFLD); male fertility; spermatogenesis; testis; liver mitochondria; reactive oxygen species (ROS); metabolic homeostasis; bile formation; Non-Alcoholic Fatty Liver Disease (NAFLD); male fertility; spermatogenesis; testis; liver

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bernardino, R.L.; Marinelli, R.A.; Maggio, A.; Gena, P.; Cataldo, I.; Alves, M.G.; Svelto, M.; Oliveira, P.F.; Calamita, G. Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends. Int. J. Mol. Sci. 2016, 17, 1096.

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