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Int. J. Mol. Sci. 2016, 17(7), 1023; doi:10.3390/ijms17071023

Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides

1
Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
2
Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
3
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala 751 24, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Ge Zhang
Received: 20 May 2016 / Revised: 20 June 2016 / Accepted: 21 June 2016 / Published: 30 June 2016
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Abstract

Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of d-amino acids (d-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of d-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that d-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of d-AA on HDPs. View Full-Text
Keywords: d-amino acid; host defense peptide; antimicrobial peptide; anticancer peptide; diastereomer; HDP; AMP; bioactivity d-amino acid; host defense peptide; antimicrobial peptide; anticancer peptide; diastereomer; HDP; AMP; bioactivity
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Li, H.; Anuwongcharoen, N.; Malik, A.A.; Prachayasittikul, V.; Wikberg, J.E.S.; Nantasenamat, C. Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides. Int. J. Mol. Sci. 2016, 17, 1023.

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