Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides
AbstractHost defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of d-amino acids (d-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of d-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that d-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of d-AA on HDPs. View Full-Text
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Li, H.; Anuwongcharoen, N.; Malik, A.A.; Prachayasittikul, V.; Wikberg, J.E.S.; Nantasenamat, C. Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides. Int. J. Mol. Sci. 2016, 17, 1023.
Li H, Anuwongcharoen N, Malik AA, Prachayasittikul V, Wikberg JES, Nantasenamat C. Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides. International Journal of Molecular Sciences. 2016; 17(7):1023.Chicago/Turabian Style
Li, Hao; Anuwongcharoen, Nuttapat; Malik, Aijaz A.; Prachayasittikul, Virapong; Wikberg, Jarl E.S.; Nantasenamat, Chanin. 2016. "Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides." Int. J. Mol. Sci. 17, no. 7: 1023.
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