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Int. J. Mol. Sci. 2016, 17(7), 1007; doi:10.3390/ijms17071007

PBK/TOPK Expression Predicts Prognosis in Oral Cancer

1
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
2
Department of Otorhinolaryngology, Head and Neck Surgery, Jen-Ai Hospital, Taichung 400, Taiwan
3
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
4
Department of Urology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
5
Department of Medical Education, Chung Shan Medical University Hospital, Taichung 402, Taiwan
6
Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan
7
Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
8
School of Optometry, Chung Shan Medical University, Taichung 402, Taiwan
9
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
10
Department of Surgical Pathology, Changhua Christian Hospital, Changhua 500, Taiwan
11
Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua 500, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Atsushi Matsuzawa
Received: 16 March 2016 / Revised: 22 April 2016 / Accepted: 20 June 2016 / Published: 24 June 2016
(This article belongs to the Special Issue Kinase Signal Transduction)
View Full-Text   |   Download PDF [1138 KB, uploaded 24 June 2016]   |  

Abstract

Oral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The association between PBK/TOPK expression and clinicopathological features was analyzed. The prognostic value of PBK/TOPK for overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. A high PBK/TOPK expression level was correlated with long overall survival. The prognostic role of PBK/TOPK expression was significant in young patients (p < 0.05), patients with smoking habits (p < 0.05), and late stage disease (p < 0.05). Our results suggest that PBK/TOPK expression is enhanced in oral cancer. High PBK/TOPK expression, either alone or in subgroups according to clinicopathological features, may serve as a favorable prognostic marker for patients with oral cancer. View Full-Text
Keywords: PBK (PDZ-binding kinase); TOPK (T-LAK cell-originated protein kinase); prognosis; head and neck cancer; metastasis; oral squamous cell carcinoma PBK (PDZ-binding kinase); TOPK (T-LAK cell-originated protein kinase); prognosis; head and neck cancer; metastasis; oral squamous cell carcinoma
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MDPI and ACS Style

Chang, C.-F.; Chen, S.-L.; Sung, W.-W.; Hsieh, M.-J.; Hsu, H.-T.; Chen, L.-H.; Chen, M.-K.; Ko, J.-L.; Chen, C.-J.; Chou, M.-C. PBK/TOPK Expression Predicts Prognosis in Oral Cancer. Int. J. Mol. Sci. 2016, 17, 1007.

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