PBK/TOPK Expression Predicts Prognosis in Oral Cancer
AbstractOral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The association between PBK/TOPK expression and clinicopathological features was analyzed. The prognostic value of PBK/TOPK for overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. A high PBK/TOPK expression level was correlated with long overall survival. The prognostic role of PBK/TOPK expression was significant in young patients (p < 0.05), patients with smoking habits (p < 0.05), and late stage disease (p < 0.05). Our results suggest that PBK/TOPK expression is enhanced in oral cancer. High PBK/TOPK expression, either alone or in subgroups according to clinicopathological features, may serve as a favorable prognostic marker for patients with oral cancer. View Full-Text
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Chang, C.-F.; Chen, S.-L.; Sung, W.-W.; Hsieh, M.-J.; Hsu, H.-T.; Chen, L.-H.; Chen, M.-K.; Ko, J.-L.; Chen, C.-J.; Chou, M.-C. PBK/TOPK Expression Predicts Prognosis in Oral Cancer. Int. J. Mol. Sci. 2016, 17, 1007.
Chang C-F, Chen S-L, Sung W-W, Hsieh M-J, Hsu H-T, Chen L-H, Chen M-K, Ko J-L, Chen C-J, Chou M-C. PBK/TOPK Expression Predicts Prognosis in Oral Cancer. International Journal of Molecular Sciences. 2016; 17(7):1007.Chicago/Turabian Style
Chang, Chin-Fang; Chen, Sung-Lang; Sung, Wen-Wei; Hsieh, Ming-Ju; Hsu, Hui-Ting; Chen, Li-Hsin; Chen, Mu-Kuan; Ko, Jiunn-Liang; Chen, Chih-Jung; Chou, Ming-Chih. 2016. "PBK/TOPK Expression Predicts Prognosis in Oral Cancer." Int. J. Mol. Sci. 17, no. 7: 1007.
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